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123 Sentences With "deleterious to"

How to use deleterious to in a sentence? Find typical usage patterns (collocations)/phrases/context for "deleterious to" and check conjugation/comparative form for "deleterious to". Mastering all the usages of "deleterious to" from sentence examples published by news publications.

But it is deleterious to our psyche and our health.
That kind of intensity could be deleterious to the songwriting process.
At this time, its unclear why this particular fungicide is so deleterious to honeybees' health.
Artificial timelines of this sort are deleterious to diplomacy and utterly unnecessary for American security.
But they could be almost as deleterious to American press freedoms in the long run.
It did look less irksome and deleterious to my mental health than what I use today.
Bosworth tells me "I think the alternatives for adblockers would be very deleterious to the user experience".
Its CEO, Lisa Dyson, thinks that process will be less deleterious to natural resources than other plant-based meat alternatives.
" But the former president said that he is afraid Bolton's "influence on President Trump will be deleterious to our country.
But the glamour could be suffocating — literally, considering the constant cloud of cigarette smoke, as deleterious to health as any satirist.
Or consider how his view of a matter, such as gerrymandering or voter registration, potentially deleterious to the Democrats, would be received.
Yet, as history demonstrates, restriction of speech might be most deleterious to the very same people that such restrictions want to defend.
If it was simply an act of destruction, that becomes deleterious to people who are proactive in making the world a better place.
Perhaps most deleterious to society is that tech companies don't always have to abide by the same regulations as their non-tech counterparts.
There is a canard that gets shamelessly trotted out by some proponents of criminal justice reform and it is deleterious to the movement.
"Also, since the replacement of collagen is slow, it would be more deleterious to do too many treatments in too short a period of time," added Keenan.
Lax enforcement of labor laws, as well as a failure to prosecute employers' violations of immigration law, are much more deleterious to working people than the specter of unauthorized migrants.
But collectively they paint a view aligned with Hughes': that the company is too large, too powerful, and too deleterious to the health of our individual psyches and of our society.
Right now, the potential is rampant for esports to become beholden to their respective sponsors at a level that is deleterious to the overall health and continued success of the industry.
Same with other causes of liver damage, including congenital defects and infections like hepatitis B and hepatitis C. "Having alcohol on board with hepatitis C is very, very deleterious to the liver," Flamm says.
SK: There's been some improvement in how we capture emissions, but [carbon emissions] are still very deleterious to our health and the planet's health, and there are a few areas to think about [to address the problem].
Attempts to address player safety have been woefully inadequate, in other words, something that first and foremost is deleterious to the health of the players, but it also further dilutes the quality of play when key contributors miss action.
Dystopian possibilities aside, what really stings about self-checkout is that right now it is not even automation, which has been so obviously deleterious to the job market but has also been, for the most part, successfully framed as progress.
"Although the toxic effects of oxidants on the Martian surface have been suspected for some time, our observations show that the surface of present-day Mars is highly deleterious to cells, caused by a toxic cocktail of oxidants, iron oxides, perchlorates and UV irradiation," the researchers wrote.
The team of scientists from University of California, Berkeley and the University of Copenhagen theorized that weak natural selection in Neanderthals' small populations (as few as 1,000 individuals at a time over a period of 400,000 years) were responsible for allowing genetic mutations—both advantageous and deleteriousto persist over time.
His persistent lies coupled with an active effort to undermine the very idea that facts actually exist -- and are not just one's opinion -- are tremendously deleterious to having a society in which we all agree on a handful of accepted norms no matter where we land on the political or socioeconomic spectrum.
And a juiced ball is better, surely, than the sanctimonious and hypocritical drug policy of two decades past that vilified players for making choices—choices deleterious to their health, no less—that they had every incentive in the world to make, while the league profited handsomely off those choices and punished players for them simultaneously.
There is no evidence, however, that fructose is the sole, or even the main factor in the development of these diseases, nor that it is deleterious to everybody, and public health initiatives should therefore broadly focus on the promotion of healthy lifestyles generally, with restriction of both sugar and saturated fat intakes, and consumption of whole grains, fresh fruits and vegetables rather than focusing exclusively on reduction of sugar intake.
Both mutations are predicted to be deleterious to protein function.
Additionally, induced mutations in these -35 and -10 promoter sequences have proven to be deleterious to transcription.
The Memati stream joins the Surmat river about a mile from this village. The water of the Memati is very deleterious to health.
Thus, outcrossing, promoted by the necessity for union of opposite mating types, likely provides the benefit of masking recessive mutations that would otherwise be deleterious to sexual spore formation (see Complementation (genetics)).
Thus, outcrossing, promoted by the necessity for union of opposite mating types, likely provides the benefit of masking recessive mutations that would otherwise be deleterious to sexual spore formation (see Complementation (genetics)).
In addition, the operating room environment must be monitored for ambient temperature and humidity, as well as for accumulation of exhaled inhalational anesthetic agents, which might be deleterious to the health of operating room personnel.
For example, left ventricular failure allows pulmonary edema and pulmonary hypertension to occur, which increase stress on the right ventricle. Right ventricular failure is not as deleterious to the other side, but neither is it harmless.
There are over a dozen yoga positions that are variant of the backbend. A "rib thrust" is common and deleterious to a good yoga pose, and one of the more common of several errors associated with the backbend.
Among other things Cohn is remembered for being the first to show that Bacillus can change from a vegetative state to an endospore state when subjected to an environment deleterious to the vegetative state. In 1885 he received the Leeuwenhoek Medal.
The underwater sound pressure caused by pile-driving may be deleterious to nearby fish.Halvorsen, M. B., Casper, B. M., Woodley, C. M., Carlson, T. J., & Popper, A. N. (2012). Threshold for onset of injury in Chinook salmon from exposure to impulsive pile driving sounds. PLoS ONE, 7(6), e38968.
President Lincoln was criticized by Democrats for working with the Board. His critics saw his cooperation with the organization as deleterious to the status quo, given that former slaves were also seeking chaplaincy posts in the Union Army.John Wesley Brinsfield, Faith in the Fight: Civil War Chaplains (Stackpole Books, 2003), 37.
The League had known how to link its corporatist demands to public discontent by using populist and nationalist slogans, but it unsettled the bourgeoisie. Although it saw the necessity of modernising the country, the middle classes feared the drift towards a military dictatorship, considered deleterious to the normal progress of affairs.
Oxford Univ. Press, 2012. . Retrieved 14 October 2012. The Hongwu Emperor curtailed the cosmopolitan culture of the Mongol Yuan dynasty, and the prolific Prince of Ning Zhu Quan even composed one encyclopedia attacking Buddhism as a foreign "mourning cult", deleterious to the state, and another encyclopedia that subsequently joined the Taoist canon.
At other times, they contract back into the safety of the skeleton. In older specimens, particularly those exceeding in diameter, the regular structure sometimes breaks down near the centre and there are growth anomalies. It has been found that these are not deleterious to the survival of the coral and may be caused by stress factors such as raised sea temperatures.
Various types of prepared fish food In the wild, the diet of goldfish consists of crustaceans, insects, and various plant matter. Like most fish, they are opportunistic feeders and do not stop eating on their own accord. Overfeeding can be deleterious to their health, typically by blocking the intestines. This happens most often with selectively bred goldfish, which have a convoluted intestinal tract.
After his term as territorial governor, Stevenson moved back to his farm. In addition to his farming activities, he won the contract for a profitable mail run. In 1894, he ran unsuccessfully for state governor. The strains of the campaign proved deleterious to Stevenson's health and he moved to Paraiso Springs in Monterey County, California in an effort to recover.
This was seen as deleterious to society and conditions for grieving were set. For instance, under some laws, women were prohibited from loud wailing or lacerating their faces and limits were introduced for expenditure on tombs and burial clothes. The Romans commonly built tombs for themselves during their lifetime. Hence these words frequently occur in ancient inscriptions, V.F. Vivus Facit, V.S.P. Vivus Sibi Posuit.
This has prompted many ISPs to offer DSL services without phone service. A new wire is simply run to the premises requiring the service, bypassing the need for any further local loop unbundling agreements. Despite the improvement of the internet in Thailand, there are still network issues, mostly concerning network latency. The delay on the network itself proved to be deleterious to competitive online gaming.
Katanin is important in the development of many organisms. Both elimination and overexpression of katanin is deleterious to axonal growth, and, thus, katanin must be carefully regulated for proper neural development. Karabay, A., Yu, W., Solowska, J., Baird, D. & Baas, P. Axonal Growth is Sensitive to Levels of Katanin, a Protein that Severs Microtubules. In particular, severing microtubules in specific cellular spaces allows fragments to test various routes of growth.
Six microsatellites were examined looking at the current population in 2008 as well as museum samples from 1895 to 1989. One of the microsatellite alleles examined has fixed within the population prior to 1895. For the current population all six microsatellites as well as all sixteen alloenzymes analyzed were fixed. Fixed alleles can often be deleterious to populations, especially when there is a small population size and low genetic variability.
Some studies suggest the effects of climate change could be quite deleterious to this current balance. As climate change occurs, it continues to increase ice melt on land and sea. Both surface water melt and river discharge are occurring earlier and in greater volume. The result of this may be a decrease in convection currents, further stratifying what is already a very stratified body of water in the late summer.
Damage to the membranes of organelles by monomeric or oligomeric proteins could also contribute to these diseases. Alpha-synuclein can damage membranes by inducing membrane curvature, and cause extensive tubulation and vesiculation when incubated with artificial phospholipid vesicles. The tubes formed from these lipid vesicles consist of both micellar as well as bilayer tubes. Extensive induction of membrane curvature is deleterious to the cell and would eventually lead to cell death.
As portrayed by Boie, the impact on the lives of the islanders was permanent and profound. More than eighty years after it first appeared, this is one novel by Margarete Boie that continues to draw readers and generate discussion. Many of Boie's books appeared with illustrations and other adornments contributed by Helene Varges. The bracing climate of Germany's northern islands, which others visited for the health benefits, proved deleterious to Boie's well-being.
There are reports that indicate amyloid polymers (such as those of huntingtin, associated with Huntington's disease) can induce the polymerization of essential amyloidogenic proteins, which should be deleterious to cells. Also, interaction partners of these essential proteins can also be sequestered. All these mechanisms of toxicity are likely to play a role. In fact, the aggregation of a protein generates a variety of aggregates, all of which are likely to be toxic to some degree.
This would cause the blood from the wound to clot and eventually heal the wound. Bloodletting, the surgical removal of blood, was used to cure a patient of bad "humours" considered deleterious to one's health. A phlebotomist performing bloodletting on a patient drained the blood straight from the veins. "Wet" cupping, a form of bloodletting, was performed by making a slight incision in the skin and drawing blood by applying a heated cupping glass.
Proceedings of the Zoological Society of London 1882:712–714. Accounts from the sugar industry in the early 20th century state that the introduced mongooses were effective at reducing the number of rats, mice, and insects. However, the mongooses have been deleterious to native birds, which evolved in the absence of mammalian predators, as well as preying on the eggs of endangered sea turtles. Only the islands of Lana'i and Kaua'i are thought to be free of mongooses.
He subsequently operated a lucrative parking lot across the street from the Forum, home of the Montreal Canadiens hockey club, in downtown Montreal. He also participated in many maverick campaigns and was an outspoken crusader against the marketing of cow's milk, which he believed to be deleterious to human health. He died at his home at 1430 Chomedey St., Montreal, on August 25, 1993. He is the father of Montreal journalists JD Gravenor and Kristian Gravenor.
Some writers have considered Alberta's highly gendered division of farm life to be not only inefficient from an agricultural standpoint, but deleterious to the integrity of marriage relationships as well. In the agricultural tradition of Central Canada there is an emphasis on conjugal (husband-and-wife) collaboration. Major decisions are normally made together, with each spouse having equal decisive power. When extended families live and farm together, couples within the extended family are considered as working "units".
This unfolding will result in loss in enzymatic activity, which is understandably deleterious to continuing life-functions. An example of such is the denaturing of proteins in albumen from a clear, nearly colourless liquid to an opaque white, insoluble gel. Proteins capable of withstanding such high temperatures compared to proteins that cannot, are generally from microorganisms that are hyperthermophiles. Such organisms can withstand above 50 °C temperatures as they usually live within environments of 85 °C and above.
The remaining blue-grey stones have a low content of chromophoric oxides and so are less deleterious to the colour of the ceramic composition after firing."Ceramics: Physical And Chemical Fundamentals" H. Salmang & M. Francis. Butterworths. 1961. Until recently flint was also an important raw material in clay-based ceramic bodies produced in the UK."Notes on the Manufacture of Earthenware" E.A.Sandeman. The Technical Press Ltd. 1921 ."Changes & Developments of Non-plastic Raw Materials", Sugden, A. International Ceramics Issue 2, 2001.
Of the four DNA damage checkpoints, two have an additional process for monitoring DNA damage other than activating p53. Before entry into S phase and during S phase, ATM/R also activates Chk1/2 that inhibits Cdc25A, a protein responsible for activating cyclin-Cdk dimers. Without cyclin dimer activation, the cell cannot transition through the cycle. These two checkpoints have additional processes for regulation because replicating damaged DNA in S phase can be deleterious to the cell and more importantly, the organism.
Russell Memorial Square, a triangular plot of land in front of the Stabroek Market, Georgetown, was named for him. The site featured a publicly funded bust of Russell. Russell Street in Georgetown was not named for him but for Lord John Russell, the English Prime Minister. Life in the tropics was deleterious to Jamieson's health, and in 1888 he retired from British Guiana's public service and sailed to Melbourne, Australia, where he set up in private practice at 39 Queen Street.
However, he thought that religious beliefs were deleterious to mental health if based on fear. Sadler and his wife moved into an Art Nouveau-style house—the first steel-frame residence in Chicago—on Diversey Parkway in 1912. The couple operated their medical practice in the building. He was a member of the American Association for the Advancement of Science and of medical associations including the American Medical Association, the American Psychiatric Association, the American Pathological Society, and the American College of Surgeons.
Japan initially viewed ASEAN as economically strategic, but remained insouciant to the association until the early 1970s. ASEAN was established at a time when the Japanese government was prioritizing the reversion of Okinawa from the United States over an active role in the ASEAN region. When Japan was rid of the Okinawa problem, attitude towards ASEAN had already turned negative. ASEAN's adoption of a neutralization policy in 1971 was deleterious to Japan's foreign policy on supporting an organization whom incorporated neutralization.
In 2018, it was reported by researchers at the University of Bath and the Max-Planck Institute for Biophysical Chemistry that the CUG sense codon in this yeast is translated by two different tRNAs, one coding for serine and one for leucine, with approximately equal probability. This is the first reported instance of a proteome that is stochastically encoded from the genome. This codon is rarely used in this species, which has led to the suggestion that stochastic encoding is deleterious to the organism.
Professor Farnsworth assembles the Applied Physics Department faculty of Mars University and Amy explains her idea, demonstrating that the reverse rotation will not be deleterious to Earth. The plan works and the machine reclaims Earth's rotational energy from Thuban 9, now spinning in the opposite direction. In recognition of her achievement, Amy receives her doctorate in applied physics, now "Doctor Wong". However, she remains with Planet Express because the job market is poor while Nibbler reconciles with Leela, appreciating that she cares for him.
Iron, usually as Fe+++ is a common constituent of river waters at very low levels. Higher iron concentrations in acidic springs or an anoxic hyporheic zone may cause visible orange/brown staining or semi-gelatinous precipitates of dense orange iron bacterial floc carpeting the river bed. Such conditions are very deleterious to most organisms and can cause serious damage in a river system. Coal mining is also a very significant source of Iron both in mine-waters and from stocking yards of coal and from coal processing.
A pharmacological chaperone or pharmacoperone is a drug that acts as a protein chaperone. That is, it contains small molecules that enter cells and serve as a molecular scaffolding in order to cause otherwise-misfolded mutant proteins to fold and route correctly within the cell. Mutation of proteins often causes molecular misfolding, which results in protein misrouting within the cell. Accordingly, mutant molecules may retain proper function but end up in parts of the cell where the function is inappropriate, or even deleterious, to cell function.
Several intronic variants have been associated with addiction and were found to alter the function of brain regions responsible for reward anticipation. This link to addiction is supported by animal models, where loss of kalirin results in altered cocaine self-administration and synaptic and expression changes in response to cocaine. Perhaps the most compelling genetic links are between kalirin and schizophrenia. Numerous missense mutations in KALRN have been identified in exome sequencing studies of schizophrenia cohorts that are predicted to be deleterious to protein function.
However, the whole dispute was proving deleterious to the war effort against the English, as both sides focused more on fighting one another than on preventing the English from conquering Normandy. In 1419, the Duke and the Dauphin negotiated a truce to allow both sides to focus on fighting the English. However, in a further parley, the Duke was murdered by the Dauphin's supporters as revenge for the murder of Orléans twelve years before. Burgundian party leadership passed to Philip III, Duke of Burgundy.
X-Men True Friends #1 (1999) While phasing, she does not physically walk on surfaces, but rather interacts with the molecules of air above them, allowing her to ascend and descend, causing her to seemingly walk on air. While phased, she is immune to most physical attacks, and has inconsistent showings of some resistance to telepathy. The density of some materials (such as adamantium) can prove deleterious to her phasing, causing her to be severely disoriented or experience pain if she tries to pass through them.Wolverine vol.
Histone proteins are among the most highly conserved eukaryotic proteins. For example, the amino acid sequence of histone H4 from a pea and cow differ at only 2 out of the 102 positions. This evolutionary conservation suggests that the functions of histone proteins involve nearly all of their amino acids so that any change is deleterious to the cell. Most changes in histone sequences are lethal; the few that are not lethal cause changes in the pattern of gene expression as well as other abnormalities.
In the contest, Bradford was supported by Democrat James Michael Curley, who was contesting with Tobin for control of the state Democratic party apparatus. As governor, Bradford governed in the fashion of his mentor, Leverett Saltonstall, with an emphasis on fiscal conservatism and social liberalism. During his administration, he advanced balanced budgets and intervened to prevent protracted strikes, which would be deleterious to the interests of business and the broader public. His administration worked to promote public housing for veterans and prevent alcoholism through treatment and prevention programs.
Bergeron v. Bergeron is a landmark child custody case decided by the Louisiana Supreme Court.Judgment of the Louisiana Supreme Court In the dispute, the Louisiana Supreme Court held that, in order to modify a custody dispute that has previously been a considered decree, the person seeking the modification bears a heavy burden of proving that the current custody is so deleterious to the child as to warrant its modification, or by clear and convincing evidence that the benefits of the change outweigh the damages that will be done to the child.
The argument begins from the observation that in equilibrium, total income must equal total output. Assuming that income has a direct effect on saving, an increase in the autonomous component of saving, other things being equal, will move the equilibrium point at which income equals output to a lower value, thereby inducing a decline in saving that may more than offset the original increase. In this form it represents a prisoner's dilemma as saving is beneficial to each individual but deleterious to the general population. This is a "paradox" because it runs contrary to intuition.
The grain boundary is the interface between two grains of a crystalline material and occur when two grains meet. They are a type of crystalline defect. It is often assumed that the open-circuit voltage gap seen in CdTe, in comparison to both single- crystal GaAs and the theoretical limit, may be in some way attributable to the grain boundaries within the material. There have however been a number of studies which have suggested not only that GBs are not deleterious to performance but may in fact be beneficial as sources of enhanced carrier collection.
Quinonoid compounds generate reactive oxygen species (ROS) via redox cycling mechanisms and arylating nucleophiles. NQO1 is employed in the removal of a quinone from biological systems as a detoxification reaction: NAD(P)H + a quinone → NAD(P)+ \+ a hydroquinone. This reaction ensures complete oxidation of the substrate without the formation of semiquinones and species with reactive oxygen radicals that are deleterious to cells. The localization of NQO1 in epithelial and endothelial tissues of mice, rats and humans indicates their importance in detoxifying agent, since their location facilitates exposure to compounds entering the body.
But Indrani being a shrew looks down Rambantu and pesters her step-daughter Kaveri. Years roll by, Rambantu (Rajendra Prasad) becomes a trustworthy servant of Zamindar, though he is illiterate has a divine talent of naturopathy to cure diseases. Meanwhile, Gireesam (Kota Srinivasa Rao) a swindler, fraudulently cracks into the Zamindar's house who entices them, takes charge of his wealth and even puts a bad eye on Kaveri (Eswari Rao). So, he ploys, by affirming her horoscope as deleterious to her spouse who will soon die after the marriage.
In most species, the terminal phase is more colourful than the initial, but a notable exception to this rule is S. cretense. They use their pectoral fins to move; the caudal fin is reserved for rapid bursts of speed. The genus Sparisoma is fairly successful, but populations have been falling somewhat because of overfishing and other human activities. However, as mentioned above, it is the main grazer of algae, but since populations have been falling, the coral reefs may be at risk, because too much algae is deleterious to coral.
The crab may be immune to or able to tolerate the jellyfish stings. It is thought that the crab benefits from using the jellyfish as a nursery because free-living, young crabs are eaten by predatory fish. Other benefits of this arrangement to the crab are a potential increase in food supply and transport to new locations. There do not seem to be any benefits to the jellyfish and the arrangement may be deleterious to it if the crab nibbles its interior tissues, as happens in some other crab/jellyfish relationships.
For instance, in People v. Melvin, cordwainers were again convicted of a conspiracy to raise wages. Unlike in Pullis, however, the court held that the combination's existence itself was not unlawful, but nevertheless reached a conviction because the cordwainers had refused to work for any master who paid lower wages, or with any laborer who accepted lower wages, than what the combination had stipulated. The court held that methods used to obtain higher wages would be unlawful if they were judged to be deleterious to the general welfare of the community.
Low levels of ribonucleotides incorporation in the nuclear genome may be tolerated. Actually, aberrant nucleic acid substrates, generated by repair pathways non-RNaseH2 dependent (due to reduced RNaseH2 activity in Aicardi-Goutières Syndrome) are thought to drive innate immune response. Alternatively, ribonucleotides might induce DNA-damage response signaling that by itself may stimulates interferon production. In summary, this study highlights the fact that the ribonucleotides can be highly deleterious to the mammalian cell, causing genome instability, and that the RNaseH2 is a critical enzyme for ensuring integrity of genomic DNA.
Analysis of hair samples has many advantages as a preliminary screening method for the presence of toxic substances deleterious to health after exposures in air, dust, sediment, soil and water, food and toxins in the environment. The advantages of hair analysis include the non-invasiveness, low cost, and the ability to measure a large number of, potentially interacting, toxic and biologically essential elements. Hence, head hair analysis is increasingly being used as a preliminary test to see whether individuals have absorbed poisons linked to behavioral or health problems.
Several mutations within KALRN have been linked to neurological disease. In autism spectrum disorder a frameshift mutation was found that is likely to lead to transcript decay, and heterozygosity. Another, found within the second GEF domain, is predicted to be highly deleterious to RhoA-GEF activity and likely affects the function of kalirin9 and 12 isoforms early in neuronal development. A patient harboring a homozygous mutation in kalirin’s spectrin repeat domain was found to have severe intellectual disability, and both truncating and missense mutations have been identified in patients with developmental delay.
N-methyl- D-aspartate (NMDA) receptors are amino acid receptors, overstimulation to which lead to increased intracellular Ca2+ level, and become deleterious to neural cell. In ischaemic or hypoxic conditions such as stroke, the concentration of glutamate in synaptic clefts is increased, and continuously stimulates NMDA receptors. Gavestinel was synthesized by substituting indole-2-carboxylate at the C-3 position with an unsaturated lateral side chain. It binds to NMDA receptor on the glycine site with high affinity, selectivity and a broad time window efficacy, thus gains interests in testing its efficacy in treating stroke.
Parasympathetic nervous activity to the heart is believed to be protective and sympathetic nervous activity, deleterious, to the heart. Especially after a heart attack, sympathetic nervous activity tends to be increased. A healthy HRT indicates the presence of a healthy amount of parasympathetic activity, countering sympathetic activity. To take a wider view, however, it may be that a healthy HRT is also an indication of a healthy brain, and is the reason small HRT also predicts a likelihood of death from non- cardiac causes as well as from cardiac causes.
Justice Frankfurter, a former professor at Harvard Law School, wrote a concurrence that centered on the principles of academic freedom, and how they would be affected by governmental interference. Joined by Justice Harlan, Frankfurter noted that "a free society [depends] on free universities", and that institutions of higher education were shielded, in part, from the intervention of governmental authorities, which would be deleterious to the "intellectual life" of the university. He ultimately concluded that: "In the political realm, as in the academic, thought and action are presumptively immune from inquisition by political authority." Justice Tom C. Clark dissented, joined by Justice Burton.
Mitochondrial damage is not caused solely by oxidative stress or disease processes; normal mitochondria will eventually accumulate oxidative damage hallmarks overtime, which can be deleterious to mitochondria as well as to the cell. These faulty mitochondria can further deplete the cell of ATP, increase production of ROS, and release proapoptopic proteins such as caspases. Because of the danger of having damaged mitochondria in the cell, the timely elimination of damaged and aged mitochondria is essential for maintaining the integrity of the cell. This turnover process consists of the sequestration and hydrolytic degradation by the lysosome, a process also known as mitophagy.
If sex work is accepted as unethical, there is then the dispute over which parties of the contract are responsible for the ethical or legal breach. Traditionally, in many societies, the legal and ethical burden of guilt has been placed largely on the sex worker rather than consumers. In recent decades, some countries such as Sweden, Norway and Iceland have rewritten their laws to outlaw the buying of sexual services but not its sale (although they still retain laws and use enforcement tactics which sex workers say are deleterious to their safety, such as pressuring to have sex workers evicted from their residences).
J.,5,147-162 Metabolic engineering continues to evolve in efficiency and processes aided by breakthroughs in the field of synthetic biology and progress in understanding metabolite damage and its repair or preemption. Early metabolic engineering experiments showed that accumulation of reactive intermediates can limit flux in engineered pathways and be deleterious to host cells if matching damage control systems are missing or inadequate. Researchers in synthetic biology optimize genetic pathways, which in turn influence cellular metabolic outputs. Recent decreases in cost of synthesized DNA and developments in genetic circuits help to influence the ability of metabolic engineering to produce desired outputs.
Selinsgrove, Pennsylvania: Susquehanna University Press. Attacked as blasphemous and deleterious to the public's moral well-being, the light- hearted play's performance triggered a notable legal case in which Claus was prosecuted: convicted on charges of public indecency, Claus was ordered to pay a ten-thousand-Belgian franc fine and serve a four-month prison sentence. The prison term was reduced to a suspended sentence after a public outcry. Claus also wrote the script of a satirical comic strip, "De Avonturen van Belgman" ("The Adventures of Belgian Man") in 1967, which spoofed the Belgian bi- lingual troubles.
For reasons unknown, Sputnik is unable to replicate and produce new virions in these bald viruses. Virophage growth is deleterious to APMV and results in the production of abortive forms and abnormal capsid assembly of APMV. In one of the experiments done by inoculating Acanthamoeba polyphaga with water containing an original strain of APMV, it was discovered that several capsid layers accumulate asymmetrically on one side of the viral particle causing the virus to become ineffective. Sputnik decreased the yield of infective viral particle by 70% and also reduced the amoeba lysis by threefold at 24h.
In essence, short interspersed nuclear elements are genetic parasites which have evolved very early in the history of eukaryotes to utilize protein machinery within the organism as well as to co-opt the machinery from similarly parasitic genomic elements. The simplicity of these elements make them incredibly successful at persisting and amplifying (through retrotransposition) within the genomes of eukaryotes. These "parasites" which have become ubiquitous in genomes can be very deleterious to organisms as discussed below. However, eukaryotes have been able to integrate short-interspersed nuclear elements into different signaling, metabolic and regulatory pathways and have become a great source of genetic variability.
However, for reasons related to gene copy number effects, possession of extra copies of certain genes is also deleterious to the daughter cells. Mitotic cyclin-CDK complexes, which are synthesized but inactivated during S and G2 phases, promote the initiation of mitosis by stimulating downstream proteins involved in chromosome condensation and mitotic spindle assembly. A critical complex activated during this process is a ubiquitin ligase known as the anaphase- promoting complex (APC), which promotes degradation of structural proteins associated with the chromosomal kinetochore. APC also targets the mitotic cyclins for degradation, ensuring that telophase and cytokinesis can proceed.
The ability for CS to deposit materials that are phase-sensitive or temperature-sensitive has positioned the technique to prepare coatings not possible with other thermal spray techniques. CS can generally be used to produce coatings of a wide variety of metals, alloys, and metal-based composites, including those materials that have an exceptionally high melting temperatures (e.g. tantalum, niobium, superalloys). The process is also valuable for depositing materials that are extremely sensitive to the presence of oxygen and will readily oxidize at modest elevated temperatures – a result which is deleterious to the performance of these materials.
At approximately 9 months gestation, the fetus's energy needs surpasses the mother's energy limitation, correlating with the average time of birth. The newly born infant can then be sustained on breast milk, which is a more efficient, less energy demanding mechanism of nutrient transfer between mother and child. Additionally, this hypothesis demonstrates that, contrary to the obstetrical dilemma, an increased pelvic size would not be deleterious to bipedalism. Studying the running mechanics of males and females, it was shown that an increased pelvic size related to neither an increased metabolic nor structural demand on a woman.
Much honey is secreted in the base of the corolla, which has the character of not being poisonous, like what is yielded by R. dalhousiae and R. argenteum. The two latter species are said to render wild honey, collected in spring (their flowering season), deleterious. To this species I give the name of Dr. Thomas Thomson, surgeon, H. E. I. C. S., late of the Thibetian Mission, son of the learned Professor of Chemistry of Glasgow University, my earliest friend and companion during my College life, and now my valued travelling companion in Eastern Himalaya."Rhododendron thomsonii", J. D. Hooker, Rhododendr.
Given these properties of DNA damage and mutation, it can be seen that DNA damage is a special problem in non-dividing or slowly-dividing cells, where unrepaired damage will tend to accumulate over time. On the other hand, in rapidly-dividing cells, unrepaired DNA damage that does not kill the cell by blocking replication will tend to cause replication errors and thus mutation. The great majority of mutations that are not neutral in their effect are deleterious to a cell's survival. Thus, in a population of cells composing a tissue with replicating cells, mutant cells will tend to be lost.
Language enhances the Darwinian fitness of the human species. Yet individual grammatical and lexical meanings and configurations of memes mediated by language may be either beneficial or deleterious to the biological host. The symbiosis is rendered more complex than just simple mutualism, both by the physiological discrepancy between language as an overall condition and the nature of individual ideas conveyed through language, as well as by the ecological difference between vertically and horizontally transmitted memes. The symbiotic theory of language propounded by George van Driem grew out of the Leiden school of language evolution, fathered by Frederik Kortlandt.
U.S. Securities and Exchange Commission (November 20, 2003). Pilgrim was accused of allowing one of his friends, Michael Christiani, the manager of a hedge fund called Appalachian Trails L.P., to use a market timing strategy which rapidly traded shares of, among other funds, the PBHG Growth Fund. Though market timing is a legal and legitimate practice still in widespread use, it had begun to be considered potentially deleterious to buy- and-hold investors. In fact, at the time charges were brought in 2003, PBA had already expelled all market timers from its funds and had allowed no such activity since December 2001.
As mentioned above, aryl and alkenyl nonaflates are useful as electrophiles in palladium catalyzed cross coupling reactions. Their reactivity generally mirrors that of the more commonly encountered triflate electrophiles, but nonaflates tend to be less prone to hydrolysis to ketones (in the case of alkenyl sulfonates) and phenols (in the case of aryl sulfonates). Their resistance to hydrolysis makes nonaflates superior electrophiles in Buchwald-Hartwig couplings, where this side reaction can be deleterious to yields of the desired product. The sodium enolates of β-ketoesters react with 1.15 equivalents of NfF to give the corresponding alkenyl nonaflates in high yield.
This sediment scoured away or buried spawning grounds for salmon and steelhead trout, causing the populations of these fish to drop to dangerous levels by the mid-1970s. The flooding was also deleterious to rail service through the Eel River canyon. After the 1964 floods, much of the topography in the Eel River drainage has been permanently damaged, and landslides occur much more often, frequently damaging local road and rail infrastructure. In 1998, after another large flood in the winter of 1996–1997 washed out sections of the line, the Northwestern Pacific became the first railroad to be shut down by the federal government for safety reasons.
Alfonsi’s claim that was the most deleterious to Jewish-Christian relations was that the Jews knew that Christ was the Son of God and still killed him. John Tolan says that “Alfonsi was the first Latin writer of anti-Jewish polemic to assert that the Jews were guilty of deicide .” In the tenth titulus of the Dialogi contra Iudaeos, Alfonsi declares “that Christ was crucified and killed by the Jews of their own spontaneous will.” He claimed that the Jewish leaders were a deceitful people that should not be trusted, and since he used to be a Jew whom followed Rabbinical Judaism, he was qualified to reveal their thinking process.
Nickeline is rarely used as a source of nickel due to the presence of arsenic, which is deleterious to most smelting and milling techniques. When nickel sulfide ore deposits have been altered to produce nickeline, often the presence of arsenic renders the ore uneconomic when concentrations of As reach several hundred parts per million. However, arsenic bearing nickel ore may be treated by blending with 'clean' ore sources, to produce a blended feedstock which the mill and smelter can handle with acceptable recovery. The primary problem for treating nickeline in conventionally constructed nickel mills is the specific gravity of nickeline versus that of pentlandite.
Upon establishing "Forough's School", some religious extremists threatened to set fire to this school, which was held at her private home. To counter this threat, she, along with her children and members of her extended family, protected the school by the force of arms, a measure that was kept in place for two years. The problem was ultimately resolved as a result of Forough's discussions with the religious leaders of Mashhad, who at first had considered presence of girls in a school environment as being against religious teachings. Having convinced the citizens that studying would not be deleterious to women, the School for Women (مدرسه بانوان) in Mashhad was formally inaugurated.
The state's policy was to house death row prisoners in solitary confinement, but lengthy appeals have created new harsh conditions of extended solitary. Convicts and their defense counsels have challenged such lengthy stays in solitary confinement, which has been shown to be deleterious to both mental and physical health, and has been considered to be "cruel and unusual punishment" under the US Constitution. In March 2019, seven members of staff at the facility were arrested for rape, smuggling items to inmates and maintaining personal relationships with prisoners. In 2020 the COVID-19 pandemic in Louisiana affected Angola, with ProPublica stating that deliberate low testing rates masked an epidemic in the prison.
In other fire departments, firefighters work shorter shifts, such as a mix of 10-hour day shifts and 14-hour night shifts. The advantage is that firefighters have shorter working hours. The disadvantage is that they may sometimes have only 12 hours to recover between one night shift and the next. The 2005 Canadian Firefighter study comparing two models with 24-hour shifts with three models requiring at least three consecutive night shifts, found that consecutive nights were shown to be more deleterious to performance than a single, long shift. Performance effectiveness 75% after two consecutive nights and lower after three, compared to 78% for a 24-hour shift.
People of China pronounce P. japonicum as bin hai qian hu (滨海前胡). Its older name was fang kui (防葵). > Feverish people should not take it because it causes one to be delirious and > see spirits. \- Tao Hongjing (456-536 C.E.) - Taoist mediator of Maoshan and > follower of Ge Hong - writing in 510 C.E. In contrast to the Korean culinary uses listed above, the plant was considered in China to be medicinal but possibly deleterious to health and likely to cause delirium in those who consumed it in quantity: > Fang k'uei, if taken in excess, makes one become delirious and act somewhat > as though mad.
By that time the circulation became well-defined, although still elongated, and the convection was still scattered. On October 29, the India Meteorological Department (IMD) designated the system as Depression ARB 02 about 885 km (550 mi) east of the Yemeni island of Socotra. Convection continued to organize and deepen as the nascent depression continued west- northwestward, steered by a ridge to the north. However, dry air from the Arabian Peninsula and cooler waters proved deleterious to the system, and the circulation became more disorganized on October 30. Despite the marginally favorable conditions, the overall structure improved on November 1, with pronounced outflow developing along the western periphery.
Amotz Zahavi used the excessive tail plumes of male peafowls as evidence for his "handicap principle". Since these trains are likely to be deleterious to an individual's survival (as their brilliance makes them more visible to predators and their length hinders escape from danger), Zahavi argued that only the fittest males could survive the handicap of a large train. Thus, a brilliant train serves as an honest indicator for females that these highly ornamented males are good at surviving for other reasons, so are preferable mates. This theory may be contrasted with Ronald Fisher's theory (and Darwin's hypothesis) that male sexual traits are the result of initially arbitrary aesthetic selection by females.
The traditional tendency of governments to manipulate interest rates around the time of general elections for political gain is thought to have been deleterious to the UK economy and helped reinforce a cyclical pattern of boom and bust. Brown's decision was popular with the City, which the Labour Party had been courting since the early 1990s. Blair presided over the longest period of economic expansion in Britain since the 19th century and his premiership saw large investment into social aspects, in particular health and education, areas particularly under-invested during the Conservative government of the 1980s and early 1990s. The Human Rights Act was introduced in 1998 and the Freedom of Information Act came into force in 2000.
These findings supports the idea that the senescence response is antagonistically pleiotropic, or that the response can be simultaneously beneficial and harmful to an organism's fitness. While the senescence response can be effective at protecting organisms from cancer at young ages, it can also cause the age-related decline in tissue function typical of many degenerative diseases in mammals. If the senescence response allowed an organism to be more likely to reach reproducing age while also being deleterious to the organism later in life, there would be little selective pressure to eliminate the harmful effects of the trait. This important concept may explain the development of aging in mammals from an evolutionary perspective.
Although distinctly different from each other, DNA damages and mutations are related because DNA damages often cause errors of DNA synthesis during replication or repair and these errors are a major source of mutation. Given these properties of DNA damage and mutation, it can be seen that DNA damages are a special problem in non-dividing or slowly dividing cells, where unrepaired damages will tend to accumulate over time. On the other hand, in rapidly dividing cells, unrepaired DNA damages that do not kill the cell by blocking replication will tend to cause replication errors and thus mutation. The great majority of mutations that are not neutral in their effect are deleterious to a cell's survival.
Islington Council issued a ruling that the building be demolished in mid-2017 due to the error, which the council withdrew after an inquiry from a legal team employed by Taha. After rescinding the first order to demolish the structure, the council issued a second in February 2018, following "an investigation" that determined the building's final design differed from the approved design. This order cited the location of the fossils within the stone facade as "[...] deleterious to the conservation area and listed buildings" due to their "haphazard" placement. In August 2019, Taha's appeal was successful and the council's planning office granted planning permission, ruling that the building "accords with the generality of what had previously been approved" and removing the demolition order.
Many locations have been displaced and reduced to islands, including Oxford University and the London borough of Deptford, which is now in the Indonesian Ocean as a part of the Cockney Islands. The solar system is equally altered: Jupiter has been deep fried by Harry Ramsden's, Mercury and Neptune have been knocked together, and there was an initiative to destroy the Moon, which according to the show was deleterious to the nightlight industry. Religion also exists in the Nebulous universe. Pieced together following the Withering, theologians conclude that there were four true deities: the evil twins Yin and Yang, Feng Shui the destroyer, and merciful Bod, based on the children's television programme Bod, the theme tune of which has become a hymn, sung in Gregorian chant.
Construction of wind farms by the electrical generating industry lead to duplication of existing power plants which were still needed as backup without increasing the utilities customer base or their output.Evans, Richard (4 May 2013) Experts warn of threat to utility shares' income The Telegraph, Retrieved 7 May 2013 Scottish Natural Heritage has stated that the decommissioning of ageing turbine structures in the future would be more deleterious to the environment than leaving the bases in place, thus littering Scotland's wild land with concrete which though they could be covered with topsoil, could lead to "oxidising and subsequent staining/contamination" and would lead to irreversible damage to the sensitive peatlands on which many are built. Alternatively, new wind farms could be built on the same site, minimising overall damage.
Sackville-West worked tirelessly to lift Woolf's self-esteem, encouraging her not to view herself as a quasi-reclusive inclined to sickness who should hide herself away from the world, but rather offered praise for her liveliness and wit, her health, her intelligence and achievements as a writer. Sackville-West led Woolf to reappraise herself, developing a more positive self-image, and the feeling that her writings were the products of her strengths rather than her weakness. Starting at the age of 15, Woolf had believed the diagnosis by her father and his doctor that reading and writing were deleterious to her nervous condition, requiring a regime of physical labour such as gardening to prevent a total nervous collapse. This led Woolf to spend much time obsessively engaging in such physical labour.
Environmental impact assessments found that this dam would be deleterious to a variety of large game animals, including big-horned sheep and elk. While the Libby Dam opened the possibilities of downstream irrigation, scientists determined that it would also destroy valuable wetland ecosystems and alter the river hydrology throughout the area of its extent, in the reservoir and far downstream. Under pressure from environmental activist groups, the Army Corps of Engineers developed a mitigation plan that represents a major departure from the previous treaty dams. This plan addressed concerns about fish by building hatcheries, acquired land to serve as grazing areas for animals whose normal ranges were submerged, and implemented a technological fix as part of the dam project that enabled control of the temperature of water released from the dam.
In July 2016 he participated in negotiations between the Armenian NSS and the representatives of Sasna Tsrer group, that held the police building in Erebuni district of Yerevan from July 17 to July 31.Yerevan: Armed group to respond to NSS’ demands by 7 pmAlek Yenikomshian: Sides in the Armed Standoff in Yerevan Negotiating for Bloodless Resolution He has been one of the main speakers at public rallies in Yerevan in the wake of the July 17 seizure of a police building. On July 27, 2016 Yenikomshian was arrested and is being held at the National Security Service detention center. His lawyer Nikolay Baghdasaryan reported that his client, who is blind and has one arm, is being kept in conditions deleterious to his health. “Yenikomshian cannot eat or move about normally. The conditions at the detention center are bad,” he said.
There was criticism of the confusion of the effects of privation (no primary attachment figure) and deprivation (loss of the primary attachment figure) and in particular, a failure to distinguish between the effects of the lack of a primary attachment figure and the other forms of deprivation and understimulation that may affect children in institutions.Rutter (1981) Maternal Deprivation Reassessed, Second edition, Harmondsworth, Penguin. The monograph was also used for political purposes to claim any separation from the mother was deleterious to discourage women from working and leaving their children in daycare by governments concerned about maximising employment for returned and returning servicemen. In 1962 WHO published Deprivation of maternal care: A Reassessment of its Effects to which Mary Ainsworth, Bowlby's close colleague, contributed with his approval, to present the recent research and developments and to address misapprehensions.
Upogebia deltaura, a mud lobster commonly found in Scottish maerl beds Further action on a much wider scale may be required. According to a recent report "Scotland's marine life could be almost wiped out within 50 years unless tough action is taken to manage the way humans use the seas". Fears were expressed by a consortium of environmental organisations that commercial fish stocks, including Atlantic cod are suffering from over-fishing, that fish farming, especially for salmon is damaging the aquatic environment, a reduction in coastal marsh habitats is affecting marine bird life, litter in densely populated estuaries such as the Firth of Clyde is affecting all forms of marine life and that the growth in off-shore tourism was deleterious to populations of, for example, basking shark. A call was made for a 'Scottish Marine Bill' to co-ordinate and manage human activity at sea and to provide more protected areas such as marine national parks.
Sprung and unsprung mass are shown Sprung mass (or sprung weight), in a vehicle with a suspension, such as an automobile, motorcycle, or a tank, is the portion of the vehicle's total mass that is supported by the suspension, including in most applications approximately half of the weight of the suspension itself. The sprung mass typically includes the body, frame, the internal components, passengers, and cargo, but does not include the mass of the components at the other end of the suspension components (including the wheels, wheel bearings, brake rotors, calipers, and/or continuous tracks (also called caterpillar tracks), if any), which are part of the vehicle's unsprung mass. The larger the ratio of sprung mass to unsprung mass, the less the body and vehicle occupants are affected by bumps, dips, and other surface imperfections such as small bridges. However, a large sprung mass to unsprung mass ratio can also be deleterious to vehicle control.
Tissue engineered heart valves (TEHV) offer a new and advancing proposed treatment of creating a living heart valve for people who are in need of either a full or partial heart valve replacement. Currently, there are over a quarter of a million prosthetic heart valves implanted annually, and the number of patients requiring replacement surgeries is only suspected to rise and even triple over the next fifty years. While current treatments offered such as mechanical valves or biological valves are not deleterious to one's health, they both have their own limitations in that mechanical valves necessitate the lifelong use of anticoagulants while biological valves are susceptible to structural degradation and reoperation. Thus, in situ (in its original position or place) tissue engineering of heart valves serves as a novel approach that explores the use creating a living heart valve composed of the host's own cells that is capable of growing, adapting, and interacting within the human body's biological system.
Oirat is endangered in all areas where it is spoken. In Russia, the killing of a large fraction of the Kalmyk population and the destruction of their society as consequences of the Kalmyk deportations of 1943, along with the subsequent imposition among them of Russian as the sole official language have rendered the language obsolescent: it is almost exclusively the elderly who have a fluent command of Kalmyk.Bitkeeva 2007; for details see Bitkeeva 2006 In China, while Oirat is still quite widely used in its traditional ranges and there are many monolingual speakers,Bitkeeva 2007 a combination of government policies and social realities has created an environment deleterious to the use of this language: the Chinese authorities' adoption of Southern Mongolian as the normative Mongolian language,Sečenbaγatur et al. 2005: 179 new educational policies which have led to the virtual elimination of Mongolian schools in Xinjiang (there were just two left as of 2009), policies aiming to curtail nomadism, and the limited occupational prospects in Chinese society for graduates of Mongolian schools.
Through this first pathway, Tn7 is preferentially directed into conjugable plasmids, which can be replicated and distributed between bacteria. However, Tn7 is unique in that it also transposes at high-frequency into a single specific site in bacterial chromosomes called attTn7. This specific sequence is an essential and highly conserved gene found in many strains of bacteria. However, the recombination is not deleterious to the host bacterium as Tn7 actually transposes downstream of the gene after recognizing it, resulting in a safe way to propagate the transposon without killing the host. This highly evolved and sophisticated target-site selection pathway suggests this pathway evolved to promote coexistence between the transposon and it host, as well as Tn7's successful transmission into future generations of bacterium. The Tn7 transposon is 14 kb long and codes for five enzymes. The ends of the DNA sequence consists of two segments that the Tn7 transposase interacts with during recombination. The left segment (Tn7-L) is 150 bp long and the right sequence (Tn7-R) is 90 bp long. Both ends of the transposon contain a series of 22 bp binding sites that the Tn7 transposase recognizes and binds to.

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