122 Sentences With "chaperoning" | Random Sentence Generator

Bullough spurns authorial chaperoning, catapulting readers directly into the Hamers' ruminations.

So the chaperoning thing was really about protecting the source of income.

Chris Pratt and Bryce Dallas Howard may be chaperoning dates in the future!

This can mean chaperoning dances, monitoring lunch periods, or being on bus duty.

Sometimes, we need to go on another vacation just to unwind from all the chaperoning.

My mom was your typical class parent, chaperoning field trips and going to PTA meetings.

They have a proven record of chaperoning hundreds of millions of emerging-market consumers onto the internet.

The day before, he had missed curfew while chaperoning another client's family visit for the inpatient facility.

So, we meet Harry (Shah Rukh Khan) after a trip chaperoning a horde of Indian tourists in Europe.

I'm getting the feeling you two don't want any more chaperoning, he said nastily, baring his yellow teeth.

Scott was spotted chaperoning his and Kourtney's three kids Saturday in Malibu, with girlfriend Sofia Richie following close behind.

Among them was Brian Martin, 760, of Montclair, N.J., chaperoning his daughter, Ella, 13, and her friend, Cate Bates, 15.

Haven's mom had been chaperoning on her strikes, but after the recent incidents, her dad will start accompanying her too.

There, Mr. Adams had the honor of chaperoning his hero, who had returned to the school to accept an award.

After a short ride in a Waymo with someone chaperoning in the driver seat, Cramer's entire opinion about driverless cars changed.

It belongs to a father of one of the students at Justine's school who he met at the dance while chaperoning.

I think especially of young folks who need transportation help and chaperoning in order to be able to attend these events.

The Cloud Cam's night vision allows chaperoning around the clock, and phone notifications will be sent when the camera detects motion.

Though the flight was successful, it&aposs not clear when exactly New Shepard will be ready to start chaperoning paying customers.

"That's the one they all want to marry," a mom who was chaperoning her daughter and a friend whispered to me.

In it, the Oscar winner plays Miss Caroline, a kindergarten teacher chaperoning a seemingly innocuous field trip to the petting zoo.

Between lesson plans, grading papers, staff meetings, and required duties like chaperoning, most teachers are at school long after the final bell rings.

Faraji and I threw ourselves into the school, joining the parent-teacher association and the school's leadership team, attending assemblies and chaperoning field trips.

But behind the Marjory Stoneman Douglas students are their less-known teachers, comforting them, guiding them through school days, chaperoning them, and marching with them.

And the older North Korean men chaperoning the squad who left the stadium during the game for cigarette breaks did so in groups of three.

He thinks about what exactly he might say to his mother to keep her from chaperoning, without thinking whether this might be lies or truth.

As far as I can tell, there is no way for adults to use it without feeling as if they are chaperoning a high school dance.

Maria Gal, a municipal worker, was chaperoning TV crews from both Romania and Hungary who were curious to see the way her village kept its customs.

"Unlike a lot of working mothers, I was still able to carve out time for parent-teacher conferences and school concerts and chaperoning field trips," says Parker.

Half the people there seemed to be chaperoning the experience in some way; publicists hovered around the edges room with iPads, and Sirius staff walked around purposefully.

Hema Maira first went to Ranthambore as a young teacher in the 1980s, chaperoning a group of students from the American Embassy School in Delhi, where she lives.

Nicki and Meek hit up Ace of Diamonds in L.A., and while they looked like they were having fun ... they seemed more like mom and dad chaperoning a dance.

From this loss comes more tragedy, and soon the sisters discover their respectable mother and her silver-haired female friends have been quietly chaperoning the town's underworld for decades.

The team's careful catering to the needs of its target community — via things like manual moderation of every profile and offering an optional chaperoning feature for in-app chats — i.e.

In January 2018, while I was chaperoning my daughter's school ice-skating trip, a sturdy third-grade boy lost control and came sliding into me from behind on his knees.

I mean, there is something that they do that's powerful about engaging with the client directly and chaperoning through the creative process, right, so I don't think we'll ever displace them.

I was in the fifth grade and my mother was chaperoning a group of girls as we were schooled on the history of Florida and the ghosts of colonial America's past.

Zendaya's father was the one to say that his daughter and the athlete were still just friends, and that he was even chaperoning just to make sure it stayed that way.

Less than a week after a shooting took the lives of 17 classmates and teachers, students and chaperoning parents made the seven-hour trip from their homes in Parkland to Tallahassee.

Instead of being the embodiment of youth like they so obviously wanted, the VMAs ended up more in the territory of a try-hard dad faking his way through chaperoning prom.

Female users can also opt for a chaperoning feature whereby all of their in-app chats are emailed to a wali/guardian, should they wish to observe this type of Islamic etiquette.

Yet, recovering in the hospital, battling the Big C — and preposterously negotiating the chaperoning of a roller-skating party — I was fiercely determined to survive, which took reconnecting to my essential self.

His success as an executive — chaperoning the career of ASAP Rocky, and giving a spark to a cache of younger rappers — was completely tied to his passionate consumption of all things hip-hop.

However, when "Crank That (Soulja Boy)" dropped, all rules went out the window and the gym teachers chaperoning the dance took the lead and instructed kids step-by-step through the Superman dance.

But she says she was completely cut out of the operation after that; she says she was chaperoning her son's school ski trip in northern Italy on the day the operation took place.

That synchronicity was ultimately the reason Destiny was here, chaperoning two youths in the nosebleed section as they waited for the redeemed to flee the floor area so the bands could come back on.

If all girls were supposed targets for the evils of the world, then why was I never assumed to need the same kind of post–school dance chaperoning as my white friends in junior high?

He starts a heavy flirtation with Jeremy, a high school teacher, after chaperoning Chase to prom (a story for a different day), but ruins things when he tries to impress his crush by acting like a pretentious asshole.

A further constraint lies in Afghanistan, where America is negotiating a wind-down of its role that will require continued help in chaperoning the Taliban—which also has mysterious ties with Pakistan's security services—towards a smooth resolution.

In Deer Park, TX, on Halloween night of 1974, Ronald O'Bryan, an optician and church deacon, was chaperoning his 8-year-old son Timothy and 5-year-old daughter Elizabeth as they trick or treated throughout the neighborhood.

The woman has filed as a Jane Doe and, in her suit, says she was chaperoning her son -- who was in elementary school -- at a hip-hop concert ... when Simmons approached and invited them backstage to meet the headliner.

The community home's staff keeps Kienholz and his housemates under 123-hour supervision, chaperoning them to work, the grocery store, doctor's appointments, and date nights, with the goal of teaching the men the risks and triggers that led to their offenses.

Ray: I broke up with my first ever girlfriend in middle school, so I wouldn't have to tell my mom I had a girlfriend—she was chaperoning us all on a school field trip, and I freaked out and did the deed right before we got on the bus.

But the breakneck pace and constant chaperoning felt suffocating, and the only viable option seemed to be drinking heavily until I joined a cluster of middle-aged women dancing wildly to an onstage band playing pimba, an up-tempo style of Portuguese shlock-pop, in a packed Alfama square.

Air and iron — desire and whalebone stays — govern the story, whose most intriguing moments don't occur between the standard-issue characters: the constrained lovers; the spoiled rich kids Cait is chaperoning on their world tour; Émile's jealous, wicked demimondaine mistress; the amoral aristocrat who seduces and discards virgins; and so on.

In the 1940s, two outlaw brothers kidnap their wealthy 14-year-old second cousin, but things get complicated when her chaperoning nun refuses to abandon her charge.

After his resignation, Amnesty International asked the Police Service of Northern Ireland to open an investigation into Murray's 1974 trip to Belfast and Wales, which involved chaperoning 30 Catholic and Protestant children.

1) #7. April 2008. Marvel Comics Dominic and Adam convinced Walter to allow the twins to go out at night on "crime patrol" confronting only petty crime, with the adults taking turns chaperoning them.Davis, Alan (w, p).

If she preferred one member of the family above another, she chose that male as her husband and her choice was final. If she hated the entire family as a group, she was fought over with little say in the matter, unless she was able to find a lover who would elope with her. If she failed to catch the eye of another male family member, the household focused on chaperoning the girl. This chaperoning involved the forceful compliance of her boy husband to engage in sexual relations with his official wife.

It came as a terrible blow to Mrs. Logan when the General became sick and died. She decided a change of scene would help her and so she traveled through Europe, chaperoning George Pullman's daughters. On her return, Mrs.

Often, for short trips where adults are required to perform other functions (such as coaching) these adults will be expected to perform chaperoning duties as well. This practice both saves money and has the potential to foster a better relationship between young people and the adults chaperoning them. A major drawback of such an arrangement is that the adults involved are often hired for other reasons besides their qualifications to supervise children and adolescents. There is, therefore, the potential that such adults may be presented an opportunity to engage in physical, emotional and/or sexual abuse of their charges.

Wilson is disheartened when describing that he interacted with his offspring without awareness they were related. Ted then showcases Hanna a picture of himself back when he worked at the camp, chaperoning Charles and Lucas, whom he described as his son's "only friend".

Gracie boarded Titanic at Southampton on April 10, 1912, and was assigned first-class cabin C51. He spent much of the voyage chaperoning various unaccompanied women. They included writer Mrs. Helen Churchill Candee, 52, and three sisters, née Lamson, who were also in their fifties: Mrs.

They arrange a date for the evening, with the friend insisting upon chaperoning. Once the two meet, the man is horrified to observe that his date is masculine, grunting, and lurching. She immediately rubs up against him, asking "Do you want to see the Angry Beaver?", a now popular quote.

He was always seen by her side, chaperoning and protecting her from crowds and possible security threats. He died at age 59 of a heart attack on 25 July 2020. His funeral held on 29 July at Yayway Cemetery. His final journey was accompanied by government officials, political colleagues and hundreds of people.

Rudolf hides again but Mitzi tells the Count where he is hidden. The Count and Mitzi leave together. Scene 2: Outside the tavern Countess Larisch, ostensibly chaperoning Mary, presents the young girl to Rudolf as he leaves the tavern. Scene 3: The Vetsera house Countess Larisch calls on her friend Baroness Vetsera.

Two of the girls are in love with Schubert's roommates, and the third, Hannerl, is chaperoning her sisters. More of Schubert's friends come to visit. The father arrives in search of his daughters. Schubert's two roommates drink with Tschöll in their courtyard, underneath a Lilac tree, and he agrees to their engagements with his daughters.

Reminding her of her childhood education in Washington D.C. she also gave back to the students by chaperoning the American Indian Youth Summit taking place in D.C. during 1998, 1999, and 2001. She accomplished all of this before officially retiring as the director of education for the Wampanoag Tribe of Gay Head in 1996.

Thinking they were doomed, Billy and Mac realized they still loved each other. Ralph kidnapped Kay after she returned from chaperoning at the prom, and tied her up in a motel room. Ralph, disguised as a cop, talked Raul into telling him places where he might find Mac and Billy. Meanwhile, Larry Warton found and rescued Kay.

At her party, Suzi tells Beth, who is chaperoning, about Skip, whom she likes and hopes will show up. When Skip arrives, Beth is attracted to him. Skip also is attracted to Beth and goes out of his way to see her without Suzi's finding out. One day, Skip enters Suzi's house, apparently looking for Beth.

When Lois takes Malcolm and Reese, they immediately arrive at the bowling alley. Right away, both Malcolm and Reese notice a pretty girl named Beth (Alex McKenna) at the party. Lois soon learns that there are no adults chaperoning, then decides to stay and chaperone it herself. Reese impresses Beth, but is repeatedly interrupted by Lois before he can tell her a joke.

Mutations in this gene lead to tuberous sclerosis. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. Hamartin coded by the gene TSC1 functions as a facilitator of Hsp90 in chaperoning of Tuberin, therefore preventing its ubiquitination and degradation in the proteasome. Alternative splicing results in multiple transcript variants encoding different isoforms of the protein.

In January 1999, Lupin the Third and Daisuke Jigen steal a diamond and hide it in a doll. Though Inspector Zenigata attempts to catch the two, he fails and they escape on an airplane. While on the plane, a little girl named Julia steals Lupin's doll. Lupin chases her and she leads him to Fujiko Mine, who is chaperoning her.

Her married-name signature, used for a short time (1907) before she reverted to using her maiden-name signature. The only year in which she used the name Harriman-Browne was in 1907 in her books, including the book about Chaperoning Adrienne. The next year, she started a publishing company, using only her maiden name, Harriman. In Seattle, on May 2, 1907, she married Seneca F. Browne.

Although most serpins control proteolytic cascades, some proteins with a serpin structure are not enzyme inhibitors, but instead perform diverse functions such as storage (as in egg white—ovalbumin), transport as in hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and molecular chaperoning (HSP47). The term serpin is used to describe these members as well, despite their non- inhibitory function, since they are evolutionarily related.

Garcia subsequently became Miss Grand Dominican Republic, and representing the Dominican Republic was crowned Miss Grand International in Bangkok on October 25, 2015. On March 24, 2016, Garcia resigned the title of Miss Grand International 2015 after saying she had been sexually assaulted while on a mission trip to South Sudan and that the organization had provided inadequate chaperoning and its president, Nawat Itsaragrisil, had not investigated.

Nicholas McKay, Sr. (December 8, 1920 – November 15, 2014) was an American inventor and entrepreneur. His most well-known (and first commercial) product was the Lint Pic-Up, the world's first lint roller. McKay had the idea after needing masking tape, a paper roll and some wire to clean his suit before chaperoning his son's high school dance in 1956. He and his late wife Helen formed Helmac the next day.

Adams published Seeing Europe Through Sightless Eyes in 1929. In this book, Adams described her personal reactions to art she was able to experience in Europe either through the descriptions of the voice student she was chaperoning or through touch. She continued to teach until 1948 and died a year later on September 8, 1949 at the age of 84. Adams was interred with her family in Lakeview Cemetery.

The teacher's work day is 7.5 hours, including a 30-minute duty-free lunch and a daily preparation period. The teachers work 182 days in the contract year. Additionally, the teachers receive a defined benefit pension, health insurance, professional development reimbursement, paid personal days, 10 paid sick days, and other benefits. Teachers receive additional compensation at $40 per hour for functions like: chaperoning, taking tickets at events, ticket sellers, scorekeepers and clock operators at events.

A month later Elizabeth wins the bonus, completing her needed funds, and books her breast enlargement. When Elizabeth learns that Amy and Scott are chaperoning an upcoming field trip, she smears an apple with poison ivy and leaves it for Amy, who ends up with blisters covering her face and cannot go. On the trip, Elizabeth seduces Scott. They dry hump and Elizabeth secretly leaves Amy a message through Scott's phone, recording all the action.

It turns out that Ted used to run a summer camp for troubled boys, and Charles was a camper there. Wilson is disheartened when describing that he interacted with a "soft-spoken, sweet" boy without awareness they were related. Ted then showcases Hanna a picture of himself back when he worked at the camp, chaperoning Charles and Lucas Gottesman, whom he described as his son's "only friend". This shocking revelation leaves Hanna stunned.

Aunt Agatha visits Bertie and tells him his cousins Claude and Eustace, who have been expelled from Oxford, are being sent to work in South Africa. She instructs Bertie to look after them for a night. Bertie is concerned his cousins will cause trouble, but Jeeves is unsympathetic because he disapproves of Bertie's new spats with Etonian colours. Claude and Eustace stay over, though most of the night they are out partying, with Bertie reluctantly chaperoning.

Reaching the Boat Deck, he realized the ship was listing slightly. He returned to his cabin to put on his life jacket and on the way back found the women he had been chaperoning. He escorted them up to the Boat Deck and made sure they entered lifeboats. He then retrieved blankets for the women in the boats, and along with his friend Smith assisted Second Officer Charles Lightoller in filling the remaining lifeboats with women and children.

As for a prince, while Betty was spending her time with Gio, Hilda kept calling Justin, who told her that he was there and was chaperoning. Justin would later go up to the coach to tell him that Hilda liked him. Hours later Tony showed up at the Saurezes to see Hilda and the two agreed to a date. In other scenarios, Amanda agreed to do a reality show with her dad, KISS rock legend Gene Simmons.

Fearing that Caldone will be the next victim, Carter is sent to the next ISS meeting in Portofino, Italy to protect Caldone. After carefully chaperoning the professor, the 3-day meeting wraps up without incident. Only after returning to America does Carter learn that Caldone has indeed become a vegetable. After studying the attendance lists of every ISS meeting in which a scientist fell ill, Carter travels to Zurich to investigate the ISS secretary, Karl Krisst.

The gene, HSP90AA1, encodes the human stress- inducible 90-kDa heat shock protein alpha (Hsp90A). Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis.

She had settled in Los Angeles by 1924 after chaperoning her client—the young, innocent Clara Bow—on her journey from New York to Hollywood. Alton had secured Bow a contract with B.P. Schulberg. Two years later, Alton had begun to try her luck at screenwriting; her first credit was on The Cowboy and the Countess, which she co-wrote with Adele Buffington. She wrote a string of screenplays through the end of the decade, ending with 1930's Call of the Circus.

Osmolytes exert their chaperoning effects indirectly by changing the interaction of the protein with solvent, rather than through any direct interaction with the protein. Unfavorable interactions between proteins and osmolytes increases the solvation of the protein with water. This increased hydration favors more compact polypeptide conformations, in which hydrophobic residues are more tightly sequestered from polar solvent. Thus, osmolytes are thought to work by structuring partially folded intermediates and thermodynamically stabilizing folded conformations to a greater extent than unfolded conformations.

Orsino died in 1500, at age 27, of unknown causes. At around the time of his death, Giulia and the Pope had become mildly estranged but his mother, Adriana, eventually brokered a peaceful separation of the two. Adriana herself continued to remain in high standing with the Pope as his friend and confidante, even chaperoning Lucrezia on her journey to wed Alfonso d'Este. Adriana died in about 1509, and the control of Carbognano passed to her erstwhile daughter-in-law, Giulia.

Frederick II's close friend and companion, Augustus, Elector of Saxony. The only political education that Frederik received came from his close friendship with his brother-in-law, Elector Augustus of Saxony (reigned 1553–86). Some authors have later stated that Augustus was "the only strong emotional support" Frederick received in his youth. Augustus, who was the husband of Frederik's elder sister Anne, took Frederik under his wing, chaperoning him on a trip throughout the Holy Roman Empire in 1557–58.

The bat-eared fox is predominantly socially monogamous, although it has been observed in polygynous groups. In contrast to other canids, the bat-eared fox has a reversal in parental roles, with the male taking on the majority of the parental care behavior. Gestation lasts for 60–70 days and females give birth to litters consisting of one to six kits. Beyond lactation, which lasts 14 to 15 weeks, males take over grooming, defending, huddling, chaperoning, and carrying the young between den sites.

In Life with Archie: The Married Life, Miss Grundy and Mr. Weatherbee realized how much they loved each other, and got married. However, in this alternative future, she died from kidney disease not long afterward, leaving Mr. Weatherbee a broken-hearted widower. In Afterlife with Archie, she and Mr. Weatherbee were chaperoning for the Halloween school dance. They took a break outside to reminisce about the time they snuck into the Cypress Cemetery as children and make references about Night of the Living Dead.

Finch remained at her post. A new sub-governess, Martha Gouldsworthy (sister to Lieutenant-General Philip Goldsworthy, a favoured equerry of the king)Princes in the Making, a study of royal education, Morris Marples, Faber & Faber 1965 – hired on Finch's recommendation – now spent frequent time with the princesses, chaperoning and supervising their studies in preparation for their lessons with their teacher Miss Planta. In 1782, the 14th royal child, Prince Alfred, sickened and died at Windsor near the age of two, despite Lady Charlotte's devoted nursing.

Mary Alice Harriman (March 12, 1861 – December 24, 1925) was a poet, author (of poetry, novels, short stories and non-fiction) and publisher. She was called the "only woman publisher in the world" in the 1911 Who's Who in the Northwest. She published books in Seattle between 1907 and 1910, and in New York after that, closing her publishing business in 1913. She wrote A Man of Two Countries, Chaperoning Adrienne; a tale of the Yellowstone national park (illustrated by Charles M. Russell) and Will Thou Not Sing.

His experiences as a schoolboy left him disillusioned with formal education: "Schools and schoolmasters", he later wrote, were "prisons and turnkeys in which children are kept to prevent them disturbing and chaperoning their parents." In October 1871 he left school to become a junior clerk in a Dublin firm of land agents, where he worked hard, and quickly rose to become head cashier. During this period, Shaw was known as "George Shaw"; after 1876, he dropped the "George" and styled himself "Bernard Shaw". In June 1873, Lee left Dublin for London and never returned.

There are many different small molecules that can function to enhance protein stability and folding, many of them can be broadly grouped into large classes based both on their structure and their proposed mechanism of action. The parameters that define these groups are not strictly defined, and many small molecules that exert a chemical chaperoning effect do not readily fall into one of these categories. For example, the free amino acid arginine is not classically defined as a chemical chaperone, but it has a well-documented anti-aggregation effect.

In Dog Days, it is revealed that Mr. Jefferson's first name is Robert. When Susan emailed him because of the note Greg sent her, it had Mr. Jefferson's first name on it. In "Old School", he is stuck chaperoning the group of extra kids (which includes Rowley and Greg), much to Greg's dismay. Later, Rowley adds poison ivy to a fire started by him and he has problems breathing the next morning, which means he and Rowley (who had spots on his body) would be going back home.

His interest in the whiptail was piqued, he said, by the fact that he was chaperoning a field trip with the Cottonwood Gulch Foundation in Arizona in 1928. His young team of Boy Scouts could catch jack rabbits and other lizards in the area, but could not catch this particular lizard. He had no idea that the plateau striped whiptail was a new species of a much studied genus that contained some species, among them C. velox, that were parthenogenic. He obtained his specimens for examination by shooting them with a .

Kidnapping Tait and Murphy, Taviner was intent on killing Tait, however he let him go after a heart to heart. Young comforted Tait in the aftermath of Niamh’s death and his subsequent kidnapping, but their close bond was shattered when Smith told Tait that Young had slept with half the relief. Sleeping with Smith whilst drunk, Young was manipulated by PC Gabriel Kent into accusing Smith of date rape. When Young was tasked with chaperoning a bank manager tied down by a bomb, Tait took the opportunity to get the truth from Young.

In October 1962, the High Point Central Baptist Association censured the Old Gold & Black for running an advertisement featuring a student mixing an alcoholic beverage in his dorm room. The controversy of the advertisement was part of ongoing tensions between university leadership and the Baptist State Convention. In response to the censure, university officials promised to Baptist board members that the ads would not reappear. In December 1989, Tim Bell, a Wake Forest student studying abroad in China, was found guilty by the Honor Council of deceiving his professors who were chaperoning the trip.

TSC1 functions as a co- chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1.

As with all ATPases, ATP binding and hydrolysis is essential for the chaperoning function of Hsp90 in vivo. Hsp90 inhibitors interfere with this cycle at its early stages by replacing ATP, leading to the regulated ubiquitination and proteasome-mediated degradation of most client proteins. As such, the nucleotide binding pocket remains that most amenable to inhibitor generation. To date, there are 23 active Hsp90 inhibitor oncology trials, and 13 HSP90 inhibitors are currently undergoing clinical evaluation in cancer patients, 10 of which have entered the clinic in the past few years.

So Marge invites him to dinner at her house with their family. After dinner, Homer panics when they start talking, and Bart and Marge explain how Homer became obsessed with the painting at the Springfield Museum of Fine Arts while chaperoning a field trip there, even dreaming about it at night. Lisa then reveals that Homer confided in her about the painting, forming a common interest between them. The two then went to the museum, only to find it closed due to being out of funds and the painting shipped off to an auction house.

Myongji Foreign Language High School was a dormitory-based foreign language high school that accepted students from all over the country, mainly through its individual and unique admission tests. The students lived in the dormitory, and studied at night under the supervision of the dormitory inspectors, who were outsourced by the school. Remaining at school on weekends and during vacation was optional, but students had to follow a strict timetable that regulated activities most of the time. In the absence of school teachers, the dorm inspectors would take the place of chaperoning the students and their activities.

Calreticulin and calnexin are also integral proteins in the production of MHC class I Proteins. As newly synthesized MHC class I α-chains enter the endoplasmic reticulum, calnexin binds on to them retaining them in a partly folded state. After the β2-microglobulin binds to the peptide-loading complex (PLC), calreticulin (along with ERp57) takes over the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporter associated with antigen processing (TAP) complex. This association prepares the MHC class I for binding an antigen for presentation on the cell surface.

" At one point, when they were stopped and interrogated by a police officer, Lee told him that her family, who could not understand Chinese, were deaf and mute people that she was chaperoning. He accepted the story and let them pass. At the Lao border, Lee met a broker and paid him to take her mother and brother across and to the South Korean Embassy in Vientiane. On her way to an airport in China to fly back to South Korea, however, she was informed that her mother and brother "had been caught as they crossed the border.

It appears that only after extraction from the membranes or large protein assembly like ribosome, can polypeptides be degraded by the proteasome. In addition to this ‘segregase’ function, p97/CDC48 might have an additional role in shuttling the released polypeptides to the proteasome. This chaperoning function seems to be particularly important for degradation of certain aggregation-prone misfolded proteins in nucleus. Several lines of evidence also implicate p97 in autophagy, a process that turns over cellular proteins (including misfolded ones) by engulfing them into double-membrane- surrounded vesicles named autophagosome, but the precise role of p97 in this process is unclear.

Dr. Benjamin Linus (Michael Emerson) is a history teacher at a high school. One day in the teachers' lounge, he has a particularly loud conversation with fellow teacher, Leslie Arzt (Daniel Roebuck), in which they complain about the lack of funding at the school, especially since Principal Reynolds (William Atherton) has made Ben watch over the kids in detention, instead of chaperoning the school's history club. John Locke (Terry O'Quinn), a substitute teacher, suggests that Ben become principal instead. While tutoring his star pupil, Alex Rousseau (Tania Raymonde), Ben learns that the principal is having an affair with the school nurse.

Stiftung Lesen acts as an advocate for reading and media competency in Germany to ensure that every child and adult in Germany develops crucial reading and media skills, and enjoys reading. Stiftung Lesen’s initiatives and programmes as well as pilot and research projects complement and build on each other. The programmes support early infant development in the family and nurseries when the basis of reading competency is laid. . Older children and teenagers are reached through projects in- and outside school, covering their future development. In addition to the children benefitting directly, actors chaperoning the children’s development such as parents, childcare workers, teachers, booksellers and librarians are integrated in the programmes.

While Louise and Gene stay home with a baby sitter, a dressed up Tina and Bob get ready for the dance of their lives (Linda even rented a limo hummer to take Bob to the dance in style). School chaperoning is basically a failure in between Linda getting jealous over Bob ogling a teacher, slapping him, crying in the girl's room, revealing she faked it to give Bob a genuine taste of middle school dance drama, and sharing smuggled alcohol. Meanwhile, Jimmy Jr. crashes Josh's school dance with Zeke, Louise, Gene, and the baby-sitter in tow. Jimmy Jr. challenges Josh to a dance-off for Tina.

In head and neck squamous cell carcinoma (HNSCC) cancer, DNAJA3 suppresses cell proliferation, anchorage-independent growth, cell motility, and cell invasion by attenuating EGFR and, downstream the signaling pathway, AKT. Thus, treatments promoting DNAJA3 expression and function may greatly aid the elimination of tumors. Additionally, DNAJA3 is implicated in neurodegenerative diseases like Parkinson's disease by virtue of its key roles in chaperoning mitochondrial proteins and mediating mitochondrial morphology in conjunction with mtHsp70. Another disease, psoriasis, is a chronic inflammatory skin disease that results from the absence of DNAJA3 activity, which then results in the activation of MK5, increased phosphorylation of HSP27, increased actin cytoskeleton organization, and hyperthickened skin.

He was also able to team with a local travel agency in chaperoning children on an annual series of large-scale school-vacation trips to California tourist attractions. Trailer was recognized as a strong advocate for children with disabilities. In 1961, Trailer (and Gold Rush) led an actual wagon train across the state of Massachusetts ending at the State House in Boston, to call public attention to the needs of the mentally retarded, and the organization The Arc (then called the Association for Retarded Citizens). Trailer insisted on including children with disabilities in his show, and is said to have been one of the first to do so.

In 1809, she was involved in the establishment of the House of Refuge in Ashe Street, Dublin, and oversaw its move to Stanhope Street in 1814 to be taken over by the new order of the Sisters of Charity. She was a generous patron of the Sisters of Charity, aiding in the fund-raising for St. Vincent's Hospital, with her chaperoning three sisters to Paris to study nursing in 1833. Alongside the sisters, Ball made visits to female prisoners in Kilmainham Gaol and to Jervis Street Hospital. She was appointed the manager to the sisters' school on King's Inns Street, a position she filled until old age prevented her from visiting.

Later that evening, Betty convinces Hilda that she shouldn't go because of the cold so Hilda gets Justin to spy on the coach, but Justin needs a chaperone, so Betty takes Hilda's place. At the school, Betty tries to get interviews, only to strike out, and when she finally gets one, its Antonella who recognizes her, as she discovers that Gio is also chaperoning at the dance. As the evening goes by, Gio shows Betty how to open up about herself and hopefully convince her that she can move on. While it may have worked wonders, it wasn't enough to convince Betty that she had feelings for Gio, even as he asked her to dance, for which she would turn him down.

Gorcey's brother David was also added, as well as (Ernie) 'Sunshine' Sammy Morrison as "Scruno," the only African-American in the group and a former child actor from the very first cast of the Our Gang comedy team. In the first few films, Dave O'Brien (familiar from low-budget westerns and serials, and as the accident-prone star of the Pete Smith comedies) played Jordan's older brother Knuckles Dolan, who always seemed to be getting roped into chaperoning the kids from adventure to adventure. O'Brien appeared in different roles as well—continuity between films was often ignored. As with the Little Tough Guys, the membership of the team changed from film to film, until Huntz Hall joined in 1941, when the lineup was somewhat stabilized.

Everyone attending the state meet receives a packet with a lanyard, name tag, a campus map, a big PJAS booklet with every presenting student's name / project title / school, in addition a Penn State magazine, PSU merchandise, and coupon to purchase discounted PSU items at the bookstore. Adults judging receive a second packet detailing their judging assignment. Because there may be a shortage of judges, some adults may get a second judging assignment – one for the AM session (senior high projects) and another for the PM session (junior high projects). Non-judging chaperones receive their chaperone duty in their packet, detailing when and where they are chaperoning; typical chaperone duties include helping to direct students at the awards ceremony or watching over the sports complex for no more than 2 hours.

After the β2-microglobulin binds to the MHC class I peptide-loading complex (PLC), calreticulinand ERp57 take over the job of chaperoning the MHC class I protein while the tapasin links the complex to the transporter associated with antigen processing (TAP) complex. This association prepares the MHC class I for binding an antigen for presentation on the cell surface. A prolonged association of calnexin with mutant misfolded PMP22 known to cause Charcot-Marie-Tooth Disease leads to the sequestration, degradation and inability of PMP22 to traffic to the Schwann cell surface for myelination. After repeated rounds of calnexin binding, mutant PMP22 is modified by ubiquitin for degradation by the proteasome as well as a Golgi to ER retrieval pathway to return any misfolded PMP22 that escaped from the ER to the Golgi apparatus.

In 2019, controversy surrounding the law erupted when a Muslim woman chaperoning her son's school field trip was told to remove her veil, sparking a debate regarding the right of private citizens to wear the scarf while taking part in school activities. Far Right politicians pushed for a ban on the scarf in such situations, citing the fact that students had to adhere to a ban on all religious head-coverings, and thus mothers should abide by the same rules. French Prime Minister Édouard Philippe defended the right of mothers to wear the hijab, claiming that secularism meant defending the religious freedoms of the people. However, French Education Minister Jean-Michel Blanquer, despite acknowledging the right of women to wear as they pleased, expressed his wish that mothers would not wear the hijab on school trips.

Chaperones were expected to exercise stern authority over their charges, this, combined with the fact that young people typically had little or no say in the choice of a chaperone, could lead to resistance and resentment on the part of the young people being supervised. One particular effect of the perceived need for the chaperoning of young women was that the early development of women's sport, already impaired by a reluctance on the part of society to accept the presence of females in organized sports, was further inhibited for several decades due to the extra costs involved in hiring chaperones. The practice of one-on-one chaperones for social occasions has largely fallen out of use in Western society. Today, the term is most often applied to parents and teachers who supervise groups of young people (often of mixed genders) at school dances, sporting events, field trips and other such events.

Human leukocyte histocompatibility complex DO (HLA-DO) is an intracellular, dimeric non-classical Major Histocompatibility Complex (MHC) class II protein composed of α- and β-subunits which interact with HLA-DM in order to fine tune immunodominant epitope selection. As a non-classical MHC class II molecule, HLA-DO is a non-polymorphic accessory protein that aids in antigenic peptide chaperoning and loading, as opposed to its classical counterparts, which are polymorphic and involved in antigen presentation. Though more remains to be elucidated about the function of HLA-DO, its unique distribution in the mammalian body—namely, the exclusive expression of HLA-DO in B cells, thymic medullary epithelial cells, and dendritic cells—indicate that it may be of physiological importance and has inspired further research. Moreover, HLA-DO is stable in complex with HLA-DM, and its exhibited instability in the absence of HLA-DM, as well as its evolutionary conservation, further denote its biological significance and potential to confer evolutionary benefits to its host.

With the Cold War rapidly coming to an end, retired CIA operative Sam Boyd has taken up freelancing as a corporate spy for cosmetics giant Maxine Gray, only to find that his hands-on style of espionage is being rendered obsolete by the capabilities of younger computer hackers. Boyd is suddenly called back in to the CIA by his superior, Elliot Jaffe, for a seemingly straightforward prisoner exchange with the KGB overseen by Colonel Pierce Grissom. Jaffe and Grissom explain that they have to use Boyd instead of an active agent to keep the operation off-the-books, since the $2 million that the Russian side demanded in addition to their own agent is being supplied by a Colombian drug cartel as a favor. Boyd is tasked with chaperoning Pyotr Ivanovich Grushenko, a KGB mole who had been caught and imprisoned ten years earlier, and the briefcase containing the money to Berlin, where they will both be traded for Benjamin Sobel, a U-2 pilot who was shot down over the Soviet Union during the 1960s.

The satirical comedy focuses on the effect talking pictures have on the entertainment industry. When the New York City vaudevillean team of Jerry Hyland, May Daniels, and George Lewis find themselves in a faltering vaudeville act, they decide to head west and present themselves as elocution experts in the hope someone will hire them to train actors unaccustomed to speaking on screen. On the train they meet gossip columnist Helen Hobart, who introduces them to megalomaniac film mogul Herman Glogauer when they arrive in Hollywood. The trio's misadventures include encounters with Lawrence Vail, a New York City playwright driven to distraction and eventually a sanatorium by studio bureaucracy and a lack of work to keep him busy; silent screen beauties Phyllis Fontaine and Florabel Leigh, whose voices sound like nails on a blackboard; two pages in 18th-century dress who periodically arrive carrying placards with announcements about Glogauer's latest doings; a ditzy receptionist who wears an evening gown to work; and aspiring actress (and proverbial dumb blonde) Susan Walker and her chaperoning stage mother.