They used magnetic resonance imaging to detect brain atrophy, or wasting, and then scored the deterioration on its degree of similarity to the brain atrophy characteristic of Alzheimer's disease.
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At approximately 20 weeks' gestation, [the patient] underwent a fetal ultrasound that suggested absence of the corpus callosum, ventriculomegaly, and brain atrophy; subsequent fetal magnetic resonance imaging demonstrated severe brain atrophy.
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Roche Holding AG: * FDA GRANTS PRIORITY REVIEW TO ROCHE'S RISDIPLAM FOR SPINAL MUSCULAR ATROPHY * FDA GRANTS PRIORITY REVIEW TO ROCHE'S RISDIPLAM FOR SPINAL MUSCULAR ATROPHY Source text for Eikon: Further company coverage:
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Instead, the cause is multiple system atrophy, a neurodegenerative disease.
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And it's led to a sense of atrophy and repetition.
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"Charlie has suffered extensive muscular atrophy," Armstrong said in court.
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Like her brother, Connie was born with Spinal Muscular Atrophy.
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Under President Obama, the designation criteria were left to atrophy.
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The lower T levels also will cause muscle mass atrophy.
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Muscles can begin to atrophy in as little as 72 hours.
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If you don't use your legs for a week, they atrophy.
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I'd think the Mafia was already starting to atrophy by then.
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He has Multiple System Atrophy (MSA), a rare nervous system disorder.
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Then over time, those muscles atrophy and the tension goes away.
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Your team's ability to resolve conflict and make decisions will atrophy.
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Spinraza treats the rare, often fatal disease spinal muscular atrophy (SMA).
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Everything ages, and everything fades — bravado and atrophy are forever intertwined.
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About 1 in 11,000 babies are born with spinal muscular atrophy.
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Spinal muscular atrophy is a condition often fatal by age 2.
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The atrophy Victoria's Secret's show suffered is a but a byproduct.
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Spinal muscular atrophy is a condition often fatal by age 2.
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Tony's last MRI said 'global diffused atrophy,' that's what they call it.
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Spaceflight causes our muscles to atrophy, especially in the legs and spine.
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Areas that Trump isn't particularly interested in have been left to atrophy.
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Second, when jobs disappear, the skills of a workforce atrophy over time.
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Male anglerfish are tiny and hang off the females and then atrophy.
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And confused, powerless atrophy is what the outside world does in response.
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Those are muscles that can atrophy, but I think they're still there.
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They chop up Pinochet, turn the ocean up too loud, practice atrophy.
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By the 2007 season, the atrophy had crept up his left forearm.
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But the navy's eviction has contributed greatly to Puerto Rico's general economic atrophy.
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Biogen, which also produces a spinal muscular atrophy treatment, was up about 1%.
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In the absence of new borrowing elsewhere in the economy, growth will atrophy.
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They've weathered networks with high demands, audiences' fickle attention spans, and creative atrophy.
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Carson KitchenLast September, celebrity chef Kerry Simon passed away from multiple-system atrophy.
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"Just like any muscle that isn't being exercised, it will atrophy," explains Anami.
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They can lose bone density, their muscles atrophy, and their eyesight gets worse.
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It also makes the world more dangerous by letting our allies' capabilities atrophy.
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Once in space, the muscles atrophy quickly because of the lack of gravity.
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Others of the fibers remain alive but shrink and atrophy as we age.
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America's ability to mobilize others in the pursuit of common objectives will atrophy.
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ALS is a terminal neurodegenerative disease that causes a person's muscles to atrophy.
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But, holding an Alzheimer's brain in your hand, you can see the atrophy.
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As expected, the volunteers who had not exercised showed considerable muscle atrophy now.
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But perhaps also because the atrophy of media freedom is a contagious disease.
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A machine creates just enough "authorized movement" to prevent your complete physical atrophy.
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Without the constant tug of gravity, bones become more brittle and muscles atrophy.
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The new brace, developed by Spanish researchers, will help children with spinal muscular atrophy.
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Spinal muscular atrophy is a degenerative illness that affects about one in 10,000 babies.
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An area which had been allowed to atrophy in the post-Cold War era.
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Of particular concern is that Russia's early warning system has been allowed to atrophy.
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Jones has Spinal Muscular Atrophy Type 2 (SMA), causing him to require wheelchair assistance.
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Reducing or virtually eliminating your physical activity can also cause your muscles to atrophy.
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We magnify our powers through trust in others, and we atrophy them through distrust.
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The cause was multiple system atrophy, a neurological disease, his brother Jay Cody said.
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The cause was multiple system atrophy, a progressive brain disorder, his son Sacha said.
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Allowing workers' skills to atrophy is bad for them and bad for the country.
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According to NASA, muscles atrophy quickly because of the lack of gravity in space.
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But when older women want treatments for vaginal dryness and atrophy, insurance companies usually balk.
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Some common examples include cystic fibrosis, spinal muscle atrophy, and Tay-Sachs disease, Sagaser says.
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But, it is the lack of neuronal input/stimulation that causes the muscle to atrophy.
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As parts of the brain atrophy, language can become impoverished and motor functions are compromised.
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While IRL communities atrophy and social media booms, America's politics get angrier and more estranged.
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Sales of spinal muscular atrophy treatment Spinraza were $364 million, missing estimate of $381.55 million.
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At best, block grants would atrophy care; at worst they would cut it very dramatically.
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Carole Scates, his partner for more than 20 years, said the cause was cerebral atrophy.
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Iris can smell like old lipstick in perfumery, with a hint of Miss Havisham atrophy.
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The cause was multiple system atrophy, a rare neurological disease, her nephew Suleiman Wali said.
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At 14 months, tests revealed that Blake had a moderate form of spinal muscular atrophy.
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We flex the brain's earning muscle over and over while letting our saving muscle atrophy.
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That has led to breakthroughs in several conditions, including cystic fibrosis and spinal muscular atrophy.
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At the very least, they say, their initiative will ensure that professional talent doesn't atrophy.
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The gene therapy treats spinal muscular atrophy (SMA), the leading genetic cause of death in infants.
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And now, after twenty years of nationwide atrophy, Generalísimo Franco is finally allowing tourists into Spain.
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Zolgensma, the $2.1 million-per-patient treatment for spinal muscular atrophy, posted $160 million in sales.
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The onetime treatment delivers life-changing benefits to infants with spinal muscular atrophy, a rare disease.
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The volatility in markets, meanwhile, is causing takeovers and issuance of shares and debt to atrophy.
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An atrophy that accelerated due to the demands places on the Intelligence Community after 85033/11.
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My body may atrophy, but thanks to my $500 gamer chair, I no longer feel it.
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" He once described a rival executive, former Allscripts CEO Glen Tullman, as a "symbol of atrophy.
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The scan revealed extensive atrophy, but her husband, a doctor, thinking it best, didn't tell her.
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Your muscles, especially in your legs, start to atrophy 'cause you're not using your legs anymore.
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They often can't speak and suffer from muscular atrophy because they can't walk or move around.
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The F.D.A. approved the treatment for children under 363 with all forms of spinal muscular atrophy.
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The injury and operation almost invariably lead to significant muscular atrophy in the affected leg, though.
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Nancy Riseman Wadler, his wife, said the cause was multiple system atrophy, a degenerative neurological disorder.
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He had a rare neurological disease, late-onset cerebellar cortical atrophy, that was misdiagnosed as Parkinson's.
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We used to call this vaginal atrophy, as the tissue becomes thinner and can even shrink.
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Nash has a rare neuromuscular disease known as SMARD, or spinal muscular atrophy with respiratory distress.
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Without dystrophin — a protein that is important for maintaining the membrane of muscle cells — muscles atrophy.
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Also, the gang from Atrophy Life, my Mothers News serial, show up for one diner scene.
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As time went on, the atrophy spread from Jeremy's left thumb to his left pinky finger.
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"If injected in small amounts over a period of months, [Botox] will atrophy the muscle," Sobel explains.
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The longer the United States fails to exercise its diplomatic muscle, the worse its atrophy will get.
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It's considered a breakthrough in the treatment of spinal muscular atrophy, a rare and devastating childhood disease.
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The technique has already led to a drug for spinal muscular atrophy that was approved last year.
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Jenny Rellick was born with spinal muscular atrophy, a degenerative disease that causes muscles to waste away.
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Research suggests the part of the brain that makes people skeptical is among the first to atrophy.
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I'm up on my soapbox now, but it's like muscles—if you don't use them, they atrophy.
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The Democratic Party, the party that embraces "engagement," is in atrophy in state legislatures across the country.
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The cause was posterior cortical atrophy, a rare form of Alzheimer's disease, her daughter Rose Dempsey said.
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If true, it reflects an atrophy in the relationship and a lack of initiative on both sides.
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Likewise, your natural tendency is to atrophy and die — physically, spiritually, financially, and in every other way.
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The idea of Sunday shows, for instance, what you just said, I didn't want it to atrophy.
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Skills atrophy unless they are used, but many low-end jobs give workers little chance to practise them.
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It's generally true that when we don't use a particular skill, the neural connections that underlie it atrophy.
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I'd be pretty surprised if we started seeing hippocampal atrophy as a result of GPS, to be honest.
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When people are thrown out of work for months or years, for example, their skills start to atrophy.
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It leads to severe and progressive muscular atrophy and weakness, including in muscles needed for breathing and swallowing.
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Without the heavy downward force of gravity, astronauts can experience muscle atrophy and bone loss, among other problems.
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Unresponsive, Abdulla had no awareness of her surroundings, was tube-fed and underwent physiotherapy to prevent muscle atrophy.
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They also had a higher risk of hippocampal atrophy than those who didn't report any drinking at all.
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For example, Biogen's Spinraza for spinal muscular atrophy (SMA) will be priced at $6900,2628 for the first year.
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Astronauts who previously went on long-term missions endured changes to their vision, muscle atrophy and bone loss.
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The U.S.-based company's primary drug is a treatment for a deadly disease known as spinal muscular atrophy.
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Zolgensma, the treatment for spinal muscular atrophy, may be approved only to be given to newborns, for example.
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The most telling atrophy of mixed doubles might be seen in the prize money at Grand Slam tournaments.
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After 9/11, Republicans claimed, not implausibly, that President Bill Clinton's administration had allowed the FBI to atrophy.
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All have accelerated the atrophy of the political center in favor of extremists on both left and right.
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And oxytocin, which activates stem-cell formation in response to tissue damage or atrophy, declines naturally with age.
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Hoagland died from complications due to posterior cortical atrophy, a dementia-related disease, CVS confirmed in a statement.
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Spinraza is the first approved treatment for the rare and often fatal disease spinal muscular atrophy or SMA.
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But email lists rapidly atrophy, and one that is seven years old is seen as a relative relic.
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And some have seen their skills atrophy or have succumbed to depression, alcoholism or drug abuse, Van Horn says.
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When I was in high school, my mom got sick and she was diagnosed with some idiopathic cortical atrophy.
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Phillips lives with spinal muscular atrophy (SMA), a genetic disease that results in the loss of voluntary muscle movement.
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Spinal muscular atrophy treatment Spinraza brought in $518 million in the quarter, beating Refinitiv IBES estimates of $6.873 million.
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The Food and Drug Administration approved a gene therapy developed by Novartis for treating spinal muscular atrophy in children.
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Spinraza is the first approved treatment for spinal muscular atrophy (SMA) and has been a major focus for investors.
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Biogen— Biogen shares rose 0.7% after the biotechnology company reported positive results for its spinal muscular atrophy drug Spinraza.
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Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, affecting one in every 10,000 live births.
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The muscle cells remained active through the hibernation period, which might help explain why those tissues do not atrophy.
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The rate of brain atrophy, as measured by M.R.I., was also slowed in those taking LMTX without other drugs.
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Spinal musclar atrophy is a rare genetic condition that prevents the body from developing a muscle protein called SMN.
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In one of Dr. Lin's studies, magnetic resonance imaging tests showed greater brain atrophy among those with poor hearing.
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And spinal muscular atrophy wasn't going to keep me from having a girlfriend, getting married or having a family.
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They intervened early enough to rescue my nerves from atrophy, though I couldn't feel my thumb for a year.
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Insurers are also restricting coverage of a similarly expensive drug, Spinraza, which treats another rare disease, spinal muscular atrophy.
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"Posting '[expletive] Trump' on Facebook every five minutes doesn't convey political resistance as much as verbal atrophy," she suggests.
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This can cause vaginal atrophy, or thinning of the vaginal walls, drying and inflammation that can make sex painful.
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Zolgensma, the Swiss drugmaker's $2.1 million-per-patient gene therapy for spinal muscular atrophy, posted $160 million in sales.
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You asked about preventing things, including hot flashes, sexually transmitted disease, sagging breasts, hair loss, vaginal atrophy and more.
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Its gene-therapy drug, Zolgensma, is expected to cure spinal muscular atrophy, but costs $2.1m per treatment in America.
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Other cargo, such as mice to test muscle atrophy and bone loss in space, was packed right before the launch.
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"MGD is a serious condition that causes damage, inflammation, and/or atrophy of the eyelid's oil glands," Dr. Silani says.
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So, for now, know that popping a birth control pill is not going to make your muscles dissolve or atrophy.
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Rare and fatal neurodegenerative disorders, including Creutzfeldt–Jakob, multiple system atrophy, and Fatal familial insomnia, are all caused by prions.
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Rather, it is how well you play in each situation that determines whether you made gains or started to atrophy.
|
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According to Metal Injection, who posted the footage, the kid is moshing to the set of Arizona thrash band Atrophy.
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" Congress, says this official agenda of House Republicans, has let its "power atrophy—thereby depriving the people of their voice.
|
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Vaginal atrophy, which usually occurs after menopause, results in thinning and inflammation of the vaginal walls due to less estrogen.
|
|
Spinraza became the first FDA approved treatment for the rare, often fatal disease spinal muscular atrophy (SMA) in December 237.
|
|
I also wasn't a candidate for vaginal prolapse surgery, because it's reserved for those with very severe cases of atrophy.
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Spinal muscular atrophy is a genetic disorder marked by severe muscle weakness, affecting the ability to breathe, speak, and move.
|
|
"They're either shutting us down or reducing us to atrophy, where we amount to zero," a well-placed source said.
|
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The drug, nusinersen, was being developed by Biogen in collaboration with Ionis Pharmaceuticals Inc, to treat spinal muscular atrophy (SMA).
|
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The left side of her body is paralyzed; the atrophy is worsening with age and impeding her already limited mobility.
|
|
Charcot-Marie-Tooth is a degenerative nerve disease that causes muscles in my arms and legs to atrophy over time.
|
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Hearing loss has also been associated with an atrophy of brain tissue in auditory regions, potentially from lack of use.
|
|
"Jessie's mom has multiple system atrophy and was not well, and his parents are in their 80s," Mr. Davis said.
|
|
We need to do more research to understand the role of these small contractions in relation to prevention of atrophy.
|
|
The consensus was that Charlie had suffered muscular atrophy and damage that would be irreversible even with the experimental treatment.
|
|
It was music of disappearance and atrophy, but not pathos: There was an inevitable logic of regeneration about the piece.
|
|
While this atrophy has been taking place, the nuclear weapon threat to America has been intensifying geographically, technologically, and numerically.
|
|
I was born nearly 55 years ago with spinal muscular atrophy, a congenital, progressive neuromuscular weakness akin to muscular dystrophy.
|
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If you don't speak up about your accelerating atrophy and your radiation limit you just die by accident on the ISS?
|
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"We've allowed the highway system to atrophy for lack of maintenance," he reported, noting that as a result, productivity has suffered.
|
|
This causes it to atrophy, like any underused muscle, and take on a more spherical shape as it loses muscle volume.
|
|
Biogen — Biogen shares gained 0.9% in the premarket after the company reported positive results for its spinal muscular atrophy drug, Spinraza.
|
|
The company plans to use installments for Zolgensma, a gene therapy for spinal muscular atrophy that's expected to get approval soon.
|
|
Curran has Spinal Muscular Atrophy, a neuromuscular disorder, and was one of the first customers to test out the new system.
|
|
Also known as Lou Gehrig&aposs Disease, ALS is a fatal, motor neuron disease that causes progressive muscle weakness and atrophy.
|
|
But those behaviors common to a healthy childhood are severely delayed or never happen for children with Spinal Muscular Atrophy (SMA).
|
|
In microgravity, these muscles are prone to atrophy, and that causes the bones in the spine to stiffen and straighten out.
|
|
I am not talking about arterial flow or atrophy of a brain stem, but about the experience of being a child.
|
|
She has focused on leg strength and balance because round-the-world sailors' legs tend to atrophy during the long voyage.
|
|
Its estrogen treatment, Imvexxy, treats vulvar and vaginal atrophy, a condition caused by the loss of female hormone estrogen after menopause.
|
|
And last month, U.S. regulators put Biogen's gene therapy program for spinal muscular atrophy on hold, but no details were disclosed.
|
|
Their skills and relationships may atrophy in ways that make it harder to go back to work when jobs become plentiful.
|
|
King Ying Low coasted through several decades of atrophy and cultural neglect that perfectly mirrored the status of its longtime neighborhood.
|
|
I atrophy in discrete regions — my right foot and then my left and then my right hand — but I don't waste.
|
|
That was really because I was drawing a bunch of stuff for Atrophy Life, and I wasn't in Puke Force mode.
|
|
Some of it is due to the simple atrophy of the muscles Congress traditionally uses to exercise authority on foreign policy.
|
|
The problem is that when you do that, when you rely on others to be your political muscle, your own muscles atrophy.
|
|
Of these, 88 patients had multiple system atrophy, which impairs the body's involuntary functions such as heart rate, blood pressure and digestion.
|
|
Over time, astronauts staying six months or more on the station can experience weakening and loss of bone mass and muscle atrophy.
|
|
Biogen (BIIB) reached an agreement to sell its spinal muscle atrophy treatment Spinraza to England's National Health Service for an undisclosed price.
|
|
"I worry that human abilities may atrophy," says Daniel Weld, a professor at the University of Washington who studies human-computer interaction.
|
|
This is long enough to be fun and not long enough for muscle atrophy, a well-known side effect of prolonged weightlessness.
|
|
The 30-year-old Fort Wayne, Indiana, man was born with Spinal Muscular Atrophy – a genetic disorder that causes progressive muscle weakness.
|
|
The FDA said the gene therapy for spinal muscular atrophy should remain on the market, even while it's still assessing the situation.
|
|
For people who are completely bedridden and do hardly any exercise, the heart muscles atrophy at about 1% a week, says Levine.
|
|
Cole is like many ripped Survivor dudes whose gym-blessed muscles atrophy on the show's starvation diet, making them weak and cranky.
|
|
Certain aspects of disability, such as amputation, paralysis, and muscle weakness, and atrophy appear sexually desirable to people who enjoy the fetish.
|
|
Enabling strangers to quickly do business frees people of the need to be nice, he argues; their trust-building skills could atrophy.
|
|
It is the first FDA-approved medicine for spinal muscular atrophy, a devastating disease that affects about one in 10,000 live births.
|
|
While the Baltic states are too small to field major navies, Poland and Germany likewise have allowed their naval forces to atrophy.
|
|
Astronauts on the International Space Station spend two and a half hours per day working out to combat atrophy, according to NASA.
|
|
Spinraza, a treatement from Biogen and Ionis for spinal muscular atrophy, or SMA, had 101 reports of serious cases, including 12 deaths.
|
|
The therapy, to be sold as Zolgensma, alters the underlying genetic cause of spinal muscular atrophy and may permanently stop the disease.
|
|
Tina and Torence Anderson's baby, Malachi, was diagnosed with spinal muscular atrophy in November 2015, when he was nearly four months old.
|
|
Between the lines: Zolgensma is a gene replacement therapy to treat spinal muscular atrophy in children younger than 2, manufactured by Novartis.
|
|
The manipulated data was submitted by AveXis, a subsidiary of drugmaker Novartis, for the spinal muscular atrophy therapy Zolgensma, the FDA said.
|
|
There is no heavy lifting or physical demands, and exercise of the brain is so necessary to avoid atrophy, Alzheimer's or dementia.
|
|
The pharmaceutical giant Novartis has treated about 200 infants with Zolgensma, its spinal-muscular-atrophy gene therapy, the company said on Wednesday.
|
|
There is no heavy lifting or physical demands, and exercise of the brain is so necessary to avoid atrophy, Alzheimer's or dementia.
|
|
Revenue was boosted by sales of its spinal muscular atrophy drug Spinraza, which contributed a 15.3 percent increase in the company's revenue.
|
|
Forced inactivity allows skills to atrophy and can contribute to mental illness, says Cornelius Katona of the Helen Bamber Foundation, a charity.
|
|
Shaheen's takedown was vitriolic: he accused Nasr of an "atrophy of religious conscience," passing judgment over his faith rather than his work.
|
|
And a more ready, refreshed crew from a reduced operational tempo helps prevent the atrophy of basic seamanship skills when deployed overseas.
|
|
And as our public health and prevention programs atrophy, chronic disease, the very thing driving health spending, is free to grow unchecked.
|
|
To ward off atrophy, buy a drawer organizer, suggested Ms. Lowenheim, who uses expandable drawer organizers from Staples in her own home.
|
|
It can have all sorts of effects, ranging from making astronauts gassy to muscle atrophy and messing with the shape of eyeballs.
|
|
Age-related muscle atrophy, which begins when people reach their 40s and accelerates when they're in their 70s, is part of the problem.
|
|
You might expect the cost of hiring an ex-president for an evening to atrophy over time as his proximity to power declines.
|
|
We have to do exercise to mitigate the effects of zero gravity on the body—muscle atrophy, loss of calcium in the bones.
|
|
Shortly before, Novartis, a Swiss giant, priced its gene therapy for spinal muscular atrophy at $2.1m, making it the world's most expensive medication.
|
|
Details: The drug, Zolgensma, has the potential to cure spinal muscular atrophy, an inherited disease that often kills babies before their second birthday.
|
|
AveXis reported topline results from a Phase 1 trial of AVXS-101 a treatment for Type 1 of genetic disease, spinal muscular atrophy.
|
|
Researchers discovered that the moderate group was three times more likely to have hippocampal atrophy compared with people who didn't drink at all.
|
|
In 2016, Ionis launched an ASO called nusinersen to treat spinal muscular atrophy, one of the most common genetic causes of infant death.
|
|
Researchers at the Spanish National Research Council have created an exoskeleton that kids with spinal muscular atrophy can wear to help them walk.
|
|
What we found was, if you do enough resistive exercise, you can halt the effects of the bone loss and the muscle atrophy.
|
|
Check out which companies are making headlines before the bell: Biogen, Ionis Pharmaceuticals - The FDA approved a new treatment for spinal muscular atrophy.
|
|
The atrophy of ideology has deprived the party of its sense of mission and a vital instrument of motivating its rank and file.
|
|
Spinraza, a first-of-its-kind medicine for spinal muscular atrophy (SMT), was approved by the U.S. Food and Drug Administration in December.
|
|
When muscles atrophy, which happens in flight, the proteins break down and their amino acids go through the bloodstream and into the liver.
|
|
After the 2015 incident, Mr. Brill said, a psychological evaluation found that Mr. DeRisi had cerebral atrophy that was likely affecting his actions.
|
|
But in recent years, manufacturers have been heavily promoting the lasers for symptoms related to vaginal atrophy, menopause, urinary incontinence and sexual function.
|
|
The gene therapy for spinal muscular atrophy (SMA) — a rare genetic disease — has brought in $361 million in sales since launching in May.
|
|
Only one company in our state would cover me because of my pre-existing condition (spinal muscular atrophy, a congenital motor neuron disease).
|
|
Disability Near the end of last year, the Food and Drug Administration approved the first drug for the treatment of spinal muscular atrophy.
|
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England's National Health Service said it had reached a deal to pay for U.S. drugmaker Biogen Inc's expensive spinal muscle atrophy treatment Spinraza.
|
|
Over time, astronauts staying for six months or more on the station can experience the weakening and loss of bone and muscle atrophy.
|
|
There are only 2 approved gene therapies in the U.S., one for a form of blindness and the other for spinal muscular atrophy.
|
|
With Atrophy scheduled for release this Friday, November 11, on Metal Blade Records, Noisey is honored to share a stream for your enrichment.
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Spinraza, from Biogen and Ionis Pharmaceuticals, is the first medicine to treat patients with spinal muscular atrophy, a rare and often fatal genetic disease.
|
|
Topical steroids are normally used to treat psoriasis, but some of these creams can cause the skin to thin, also known as epidermal atrophy.
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This stress-atrophy effect is most pronounced in people with PTSD, whose hippocampi tend to have smaller volumes and less activation during memory tasks.
|
|
At Biogen he helped define the company's therapeutic area and scientific strategies for Alzheimer's disease, multiple sclerosis, spinal muscular atrophy, Parkinson's, neurodegeneration and hemophilia.
|
|
The Food and Drug Administration on Friday approved Novartis' $2.1 million gene therapy for spinal muscular atrophy — making it the world's most expensive drug.
|
|
The FDA on Friday approved Zolgensma, a gene replacement therapy from Novartis that treats spinal muscular atrophy, for use in children younger than 2.
|
|
"It's so negative-gravity that if I sit in it for, like, six hours, my muscles atrophy," he claims of the notorious furniture piece.
|
|
She's used a wheelchair for most of her life, since she suffers from spinal muscular atrophy — a condition that weakened her legs during childhood.
|
|
Dr. Gauthier said it was the first time a reduction in brain atrophy had been seen in a clinical trial of an Alzheimer's drug.
|
|
A new medical treatment with tremendous potential to treat babies born with a rare disease called spinal muscular atrophy just got approved this year.
|
|
Earlier this month, the health insurer UnitedHealth reversed denials for two individuals with spinal muscular atrophy after the Washington Post wrote about their stories.
|
|
Ben Mattlin: I was born and raised in New York City, with a neuromuscular weakness called spinal muscular atrophy (type two, to be specific).
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Progressive and irreversible geographic atrophy affects more than 5 million people worldwide, impairing reading, driving, recognizing faces, and activities in dim or low light.
|
|
The drug costs $750,000 the first year and treats the rare condition spinal muscular atrophy that often kills babies within months of their birth.
|
|
Canceling "Roseanne" is not society regulating "mean" speech; it is us regulating our collective morality, so that we don't atrophy into a moral vacuum.
|
|
Ben Mattlin, the author of the essay, was born with spinal muscular atrophy, an incurable neuromuscular condition that has caused him to be quadriplegic.
|
|
While the therapy has shown transformative benefits to newborns with spinal muscular atrophy, it has also stirred controversy over its $2.1 million list price.
|
|
With King Bhumibol Adulyadej old and ailing, many worried the Thai monarchy would atrophy into irrelevance once his playboy son ascended to the throne.
|
|
The FDA is also expected to decide on whether to approve a gene therapy for spinal muscular atrophy from Novartis AG later this year.
|
|
Risdiplam met the primary endpoint in a pivotal clinical trial in infants with type 1 spinal muscular atrophy, the Swiss drugmaker said on Thursday.
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The pharmaceutical giant Novartis has treated about 200 infants with Zolgensma, its $2.1 million spinal-muscular-atrophy gene therapy, the company said on Wednesday.
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The company also plans to explore the range of motion in the human body and how muscle development and atrophy are affected without gravity.
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Working as an Uber driver might help make ends meet in the short term, but the experience actually causes skills to atrophy over time.
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To combat muscle and bone atrophy in space, NASA launched the Digital Astronaut Project, which uses computer simulations to improve astronauts' already rigorous exercise routines.
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The company's growth driver Spinraza, used for treating spinal muscular atrophy, brought in $518 million in the quarter, beating Refinitiv IBES estimates of $23 million.
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In the article, Brazile scolds her predecessors at the DNC and scolds President Obama and his allies for allowing the party's fundraising apparatuses to atrophy.
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Separately, Novartis won U.S. approval for its gene therapy, Zolgensma, for spinal muscular atrophy and priced the one-time treatment at a record $2.1 million.
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Due to atrophy at home and competition abroad, the U.S. nuclear industry is increasingly at risk of losing power plants, workforce talent and global business.
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The FDA has approved Zolgensma, a gene replacement therapy from pharmaceutical company Novartis that treats spinal muscular atrophy, for use in children younger than 2.
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The company's growth driver Spinraza, used for treating spinal muscular atrophy, brought in $518 million in the quarter, beating Refinitiv IBES estimates of $486.4 million.
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He was then diagnosed with spinal cord atrophy, "which essentially means he's paralyzed from the chest down," his dad, Taylor Moreland, told the news outlet.
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What was surprising to researchers, however, was that moderate drinkers appeared to change, too, and they had higher risk of hippocampal atrophy than non-drinkers.
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If Congress fails to provide NASA with critical resources in future budget legislation, American space dominance will atrophy and we will all suffer the consequences.
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The drugmaker also noted that it was testing Zolgensma in older patients with spinal muscular atrophy, in hopes of getting the therapy approved for them.
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Genetic tests can be done either for chromosomes or for fatal and serious single gene disorders including spinal muscular atrophy, cystic fibrosis and muscular dystrophy.
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Netflix has let its library atrophy, and Hulu is making a to-do about its FX partnership, but it doesn't even have every FX show.
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We need public solutions for midlife career atrophy and joblessness so that people don't get into even deeper debt and blame themselves for their failures.
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When that limb is immobilized, its muscles will atrophy, losing size and strength, a process that begins within days or even hours of an injury.
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People with the disease have a genetic flaw that makes them produce too little of a protein that supports motor neurons, leading muscles to atrophy.
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Shane has a condition called spinal muscular atrophy, a type of muscular dystrophy that means his muscles are incredibly weak, while Hannah is able-bodied.
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This makes sense, given how much more often gynecologists give women pelvic exams that would show changes in the vulva and vagina and any development of atrophy, and because gynecologists are more familiar with hormones that might be prescribed to relieve some symptoms of vulvovaginal atrophy, said lead study author Dr. Kimberly Vesco of the Kaiser Permanente Center for Health Research Northwest in Portland.
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Venter is happy for his "age-related atrophy" report to be displayed here on a screen, given the good news about how young his brain looks.
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On the other hand, we know that human bones and muscles can atrophy terribly in zero gravity — as seen in experiments on the International Space Station.
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It caused nerve damage and vaginal atrophy, her medical records show, that prevented her from having sex with her husband, and she had trouble conceiving naturally.
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The potential long-term health consequences of the triad are dire: increased risk of osteoporosis and bone fractures, heart attacks, infertility, and vaginal and breast atrophy.
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Bolen, a 14-year-old from Appleton, WI, has Type 2 spinal muscular atrophy, an incurable disease that causes muscle wasting as well as chronic pain.
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As they disobey and dismantle state institutions, those institutions atrophy, laws become ineffective, liberty gets eroded, and the key functions of government fall by the wayside.
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Jerika Bolen, 14, who suffers from Type 2 Spinal Muscular Atrophy, garnered widespread attention earlier this year by speaking openly about plans to end her life.
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The two friends are avid travellers but found that it was a lot of work to organise trips: both have Spinal Musular Atrophy and use wheelchairs.
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"Excessive swelling for extended periods can cause atrophy of the muscles around the joint, thus leading to weakness and becoming susceptible to future injury," he says.
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NEW YORK (Reuters) - England's National Health Service said it had reached a deal to pay for U.S. drugmaker Biogen Inc's expensive spinal muscle atrophy treatment Spinraza.
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Her early entry into the world came with kidney problems and cerebral atrophy that have delayed some parts of her development and kept her limbs spindly.
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That trip, and the astronauts' potential time spent in Martian gravity -- 38% of the surface gravity on Earth -- creates the potential for muscle atrophy and deconditioning.
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The team's future research will also look at reported neck issues, where there can be even more occurrences of muscle atrophy and a slower recovery period.
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"The FDA supports the continued marketing and use of Zolgensma for patients with spinal muscular atrophy (SMA) less than 2 years of age," the statement read.
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That puts Zolgensma's annual list price at $425,000, which Novartis said is less expensive than Spinraza, a competing therapy for spinal muscular atrophy made by Biogen.
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Fair's team defines brain age in terms of the functional connections between regions, but Cole employs it as an index of atrophy—brain shrinkage—over time.
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Last week, Swiss drugmaker Novartis AG priced its one-time gene therapy for spinal muscular atrophy at $2.1 million, the highest price ever for a drug.
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Accentuating such natural atrophy of mine production are the temporary suspensions initiated in reaction to low prices such as Nyrstar's mothballing of its Middle Tennessee mines.
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Spinal muscular atrophy does damage to nerve cells that can't be reversed, though drugs like Zolgensma can improve survival and help with muscle control and function.
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"We recognize the severity of severe spinal muscular atrophy and we empathize with the children who have SMA, as well as their families," the spokeswoman said.
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About 400 babies are born with spinal muscular atrophy in the US each year, and the disease is the leading genetic cause of death in infants.
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Crawford recommends that patients who are waiting months for an insurance authorization consider Spinraza, since when it comes to spinal muscular atrophy, early treatment is crucial.
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She wants to bridge cultures In videos posted last year to YouTube, Carla Valpeoz said she was diagnosed with optic nerve atrophy when she was 10.
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Laurie's death had extra significance for me, a 53-year-old husband and father of two, in part because we shared a diagnosis: spinal muscular atrophy.
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"Argentina's armed forces began to atrophy after the end of the military rule," said Dan Wasserbly, the Americas editor of IHS Jane's, a defense-industry publication.
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The girl, whose name and other details were not given, has spinal muscular atrophy, a rare disease that affects movement and strength and requires lifelong treatment.
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With the AveXis deal last year, he added the gene therapy Zolgensma, now the highest-priced one-time treatment at $2.1 million, for spinal muscular atrophy.
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If we allow Congress to significantly reduce those programs, the top 1 percent essentially will have it all, and the middle class will continue to atrophy.
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A ship's attention to basic seamanship skills can atrophy after the intense warfare readiness work-up period followed by an equally intense operational tasking once deployed.
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For disability rights activist Kelly May Perks-Bevington, sex was a way of showing able-bodied people that she was more than her spinal muscular atrophy.
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There are multiple reasons for this scarcity, including general internet atrophy and specific targeted purges of content from various fanfiction websites over the years — namely Fanfiction.net.
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Every single one had dental disease and decreased muscle mass known as muscle atrophy and it's going to require ongoing physical rehabilitation so they can walk normally.
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The price tag, set Friday, makes the drug the second most expensive in the world behind Swiss drugmaker Novartis' $2.1 million gene therapy for spinal muscular atrophy.
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Hudson has proved a tenacious salesman at Novartis, winning approval for the world's costliest medicine, gene therapy Zolgensma for spinal muscular atrophy, at $2.1 million per patient.
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Above all, the political atrophy of our present moment will accelerate toward a graceless, enervating denouement as polarization and social fragmentation continue to undercut our vital center.
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It is also moving into Phase III trials with partner Ionis Pharmaceuticals, formerly Isis, of nusinersen for spinal muscular atrophy, a leading genetic cause of infant mortality.
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She wants to bridge cultures In videos posted last year to YouTube, Valpeoz says she was diagnosed with optic nerve atrophy when she was 10 years old.
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In the last several years, Biogen shifted its focus from developing multiple sclerosis drugs to treating spinal muscular atrophy — a leading cause of infant deaths — and Alzheimer's.
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If Democrats re-take either chamber of Congress in November, they are obligated to resuscitate that function Republicans have allowed to atrophy in service to their president.
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This year, 400 children with spinal muscular atrophy – now the #1 cause of death for infants — have been treated with a DNA drug developed from Cleveland's research.
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The study also serves a secondary purpose of allowing them to determine countermeasures for muscle atrophy, which can occur in space or for patients on bed rest.
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In the years since I was recruited to provide technical analysis for the Office of Technology Assessment, Congress has allowed its support agencies and committees to atrophy.
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Astronauts and researchers have identified issues like visual impairment, musculoskeletal injuries, bone density loss, muscle atrophy, vulnerable immune systems and post-mission renal stones during and after spaceflight.
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His daughter Elizabeth Gordon Rosenfeld said he died after having a stroke and attributed the death as well to complications of multiple system atrophy, a rare neurological disorder.
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Because long-term trials of lasers for vaginal atrophy haven't been completed yet, "the exact adverse effects of lasers really remain to be determined," Krychman said by email.
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And Google understands that your interests wax and wane over time, so if you stop searching for something the algorithm allows that topic to atrophy in your feed.
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In August 2005 I travelled with May Murphy, a 75-year-old widow who was suffering severely from multiple systems atrophy, from her home in Glasgow to Dignitas.
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There's a heavy emphasis on condoms and lube, but it's the phrases "vaginal atrophy" and "why can't you wear your little love mittens?" that really stick with you.
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Here is a chart from McKinsey: So, with China continuing to atrophy and still piling on debt, the currency will decline — despite China's best intentions to support it.
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The Dragon cargo spacecraft riding on the Falcon 9 will be carrying up a number of science experiments, including live mice that will help researchers study muscle atrophy.
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Another concern is about Congress — Murphy said there's an "atrophy of the muscles of Congress" in its failure to act on authorizing use of military force for years.
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They didn't know it then, but the symptom was a telltale sign of a rare, inherited disease called spinal muscular atrophy that severely affects a child's muscle movement.
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Adding to the parents' frustration, the drug needs to be given as soon as possible, because damage from spinal muscular atrophy accumulates over time and can't be reversed.
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A long-term follow-up of people with REM sleep behavior disorder showed that most developed conditions such as Parkinson's disease, Lewy body dementia or multiple system atrophy.
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Parents have been especially frustrated because the drug needs to be given as soon as possible; damage from spinal muscular atrophy accumulates over time and can't be reversed.
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Just hours prior, Nico, who has a nervous system genetic disorder known as spinal muscular atrophy, met Betts, his favorite baseball player, through the Make-a-Wish Foundation.
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"Before we learned that Pap smears could safely be discontinued at age 65 for most women, gynecologists regularly saw the changes of vulvovaginal atrophy," Vesco said by email.
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Lack of time and lack of patient education materials about symptoms and treatment were the reasons doctors cited most often as barriers to diagnosing and treating vulvovaginal atrophy.
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Spinraza, a drug approved in 260 that also treats spinal muscular atrophy, costs $2.13,22.1 in the first year of treatment and then about $236,212 a year after that.
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Ms. Anderson said many parents with children who have spinal muscular atrophy are excited about the arrival of Zolgensma, but anxious about how it will be paid for.
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With his vast experience, he's uniquely capable of being able to rebuild much of what Donald Trump has torn down or let atrophy, such as our State Department.
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And in bypassing already weak local police and judges, the government allowed those institutions to atrophy, with money and political attention diverted to military and federal forces instead.
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Born in Japan with full vision, Ms. Hashimoto trained as a classical ballet dancer into her teenage years, when her sight began deteriorating because of optic nerve atrophy.
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Sales of Spinraza, the first approved treatment for spinal muscular atrophy, rose to $543.2 million, but missed the average analysts' estimate of $549 million, according to Refinitiv data.
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In addition, sleep problems could make the brain less efficient at removing waste and contribute to loss of brain cells or atrophy in key regions of the brain.
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Biogen will focus on developing drugs for neurodegenerative diseases such as multiple sclerosis, spinal muscular atrophy (SMA), Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and neuropathic pain.
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However, the term vaginal atrophy — while technically medically accurate for some menopause-related changes — sounds dismissive and neglects the fact that these changes affect more than the vagina.
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Sales of Spinraza, the first approved treatment for spinal muscular atrophy, rose to $543.2 million, but missed the average analysts' estimate of $549 million, according to Refinitiv data.
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The study will test the use of artificial gravity to prevent the muscle and bone atrophy that plagues astronauts when they spend extended periods of time in space.
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Worse, our reliance on GPS might be causing our innate navigational capabilities to atrophy over time, leaving us helpless when technology fails and we're forced to orient ourselves.
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That led to severe nerve damage, which led to severe muscle atrophy, which made me, a former college football player, physically weaker than my then 9-year-old daughter.
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These laser treatments are approved for other gynecologic and dermatologic conditions, however, and the current study examines the cases of four women whose doctors tried it for vaginal atrophy.
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In theory, lasers could offer a nonhormonal option for vaginal, atrophy, said the coauthor of an accompanying editorial, Dr. JoAnn Pinkerton, executive director of the North American Menopause Society.
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In May, Novartis gave a similar reasoning on pricing for its one-time treatment for spinal muscular atrophy, a muscle-wasting disease and leading genetic cause of infant mortality.
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Another current treatment for spinal muscular atrophy for children and adults is Biogen's Spinraza, which has a list price of $750,000 for the first year and $375,000 annually thereafter.
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But even after that repeal effort failed, the CHIP funding deadline came and went, the House passed a partisan bill funding the program, and Hatch's negotiations continued to atrophy.
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Older participants who have been chronic heavy drinkers show even more significant memory deficits, and their brains can actually atrophy — similar to the effects of a severe vitamin deficiency.
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Brains shrink as people age, and the atrophy is related to cognitive decline and increased risk for dementia, a researcher said, and exercise reduces that deterioration and cognitive decline.
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Over the next two years, engineers will assess how long-duration sedation affects our organs and how to counteract bone loss and muscle atrophy that occurs during deep sleep.
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The global eczema drug market is currently worth about $313 billion in sales, mostly of topical steroids than can cause skin atrophy and increase risk of glaucoma and cataracts.
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Biogen is widely expected to get U.S. approval in coming months for the first drug that would treat spinal muscular atrophy, the leading genetic cause of death in infants.
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Biogen tumbled as much as 6 percent on Monday, after a rival drugmaker reported its experimental drug for spinal muscular atrophy helped a majority of babies who received it.
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It turns out, participants who reported higher levels of drinking were more likely to have a shrunken hippocampus, with more pronounced atrophy on the right side of the brain.
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It tells the story of three people — including a fiftysomething woman who recoils at being touched and a man crippled by spinal muscular atrophy — struggling with issues of intimacy.
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I was born with spinal muscular atrophy, a congenital, progressive, incurable neuromuscular condition, but my lifelong disability has never prevented me from doing anything I set my mind to.
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In May, Swiss drugmaker Novartis won U.S. approval for its gene therapy for spinal muscular atrophy and priced it at $2.125 million, making it the world's most expensive drug.
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Fda breakthrough therapy designation for avxs-101 gene replacement therapy for spinal muscular atrophy type 1 Source text for Eikon: Further company coverage: (Bengaluru Newsroom +1-646-646-8780)
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ZURICH, Jan 23 (Reuters) - Roche's risdiplam met the primary endpoint in a pivotal clinical trial in infants with type 1 spinal muscular atrophy, the Swiss drugmaker said on Thursday.
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Medicaid not only gave Mike a lifeline, but a life into adulthood after Karen was told he would not see his first birthday because of his spinal muscular atrophy.
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First, after I sent out last week's newsletter, the FDA bestowed an approval on the first gene therapy for spinal muscular atrophy, a treatment called Zolgensma that's made by Novartis.
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Related: Canada's Assisted Suicide Law Doesn't Go Far Enough, Some Say Leading the case is a 25-year-old BC woman who has spinal muscular atrophy and uses a wheelchair.
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The magnetic resonance imaging (MRI) scans revealed signs of brain abnormalities suspected of being associated with CTE, including atrophy of parts of the brain and diffuse white matter, for example.
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More likely, it would atrophy into a loose club propped up by hollow institutions unable to help governments find solutions to common problems, from trade to migration to climate change.
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Two additional pillars of Narasimhan's growth plans are Zolgensma, the gene therapy for rare spinal muscular atrophy (SMA), and Aimovig, the migraine drug on which Novartis has partnered with Amgen.
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The therapy, Zolgensma, is a one-time treatment for spinal muscular atrophy, a muscle-wasting disease and leading genetic cause of infant mortality that affects one in every 11,000 births.
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Driving the news: The approval of Zolgensma, a gene therapy with the potential to cure spinal muscular atrophy, "could come any day," said Dave Lennon, president of Novartis-acquired AveXis.
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Jonin and his collaborators eventually found that when KA was born, a heart problem led to his brain lacking oxygen for several minutes—leading to the atrophy in his hippocampus.
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A. I argue in this book, as well as a previous one, "China's Communist Party: Atrophy and Adaptation," that political decline is an inevitable and protracted process in Leninist regimes.
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Zolgensma, a rival treatment to Biogen Inc's Spinraza, was approved in May as a one-time treatment for spinal muscular atrophy (SMA), the leading genetic cause of death in infants.
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But the woman had few other neurological signs of the disease — not much of a protein called tau, which forms tangles in Alzheimer's brains, and little neurodegeneration or brain atrophy.
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Four parents of children born with the disease, called spinal muscular atrophy, told Business Insider they have been fighting health insurers like Aetna and Anthem to get access to Zolgensma.
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Four parents of children born with the disease, called spinal muscular atrophy, told Business Insider they had been fighting health insurers like Aetna and Anthem to get access to Zolgensma.
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A new, one-time treatment for spinal muscular atrophy was approved in the US this year, creating new hope for kids like Jackson who are younger than 2 years old.
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"If you will it, it is no dream," Theodor Herzl, an architect of modern Zionism, said, but Fania suffers precisely from an atrophy of will and an inability to dream.
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Overall, gynecologists got correct answers to knowledge questions about vulvovaginal atrophy 77 percent of the time on average, compared to 63 percent for primary care providers, researchers report in Menopause.
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Little things like the right Zoom lighting and switching up which leg you're putting weight on can make a big difference in how people perceive you and stave off atrophy.
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Birds may "get zapped," Mr. Thomsett said, and then fly hundreds of miles away, only to die a week or two later when their damaged limbs atrophy and become necrotic.
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What it was: Srin Madipalli and Martyn Sibley, two friends with spinal muscular atrophy, founded Accomable to make it easier for travelers with disabilities to find accessible places to stay.
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Cosentyx's sales for the 12-month period rose 28% to $3.6 billion, heart drug Entresto was up 71% to $1.7 billion and Zolgensma for spinal muscular atrophy hit $361 million.
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Spinraza, a spinal muscular atrophy (SMA) drug, generated $8.13 million in U.S. sales in the third quarter, lagging analysts' average estimate of $28.1 million, according to broker SunTrust Robinson Humphrey.
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"As Chinese weapons and equipment improve in quality and Russia's defense industry continues to atrophy, Chinese manufacturers will likely displace Russian defense industries in many key markets," said RAND's Heath.
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Spinraza, a first-of-its-kind medicine for spinal muscular atrophy, the leading genetic cause of death in infants, was approved by the U.S. Food and Drug Administration in December.
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Jerika Bolen, 14, has spinal muscular atrophy type 2, a disease that "destroys nerve cells in the brain stem and spinal cord that control voluntary muscle activity," according to Post-Crescent.
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The muscular atrophy he developed as a result of the coma left him too weak to speak, stand, or swallow (he ate through a feeding tube that went into his stomach).
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The Air Force needs to buy the stealthy jets as its currentfighters atrophy, and manufacturer Lockheed Martin has dedicated a nation-sized marketing and lobbying budget to keep the program going.
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Novartis added to its expanding gene-therapy business by agreeing to pay $8.7bn for AveXis, which specialises in treatments for spinal muscular atrophy, a genetic condition that causes progressive muscle wasting.
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"The site was inspired by her but our message is to all children diagnosed with neuromuscular disabilities," says Wolinsky, 38, of Austin, who has Spinal Muscular Atrophy and is wheelchair-bound.
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Meanwhile, he spent $8.7 billion to take over U.S.-based Avexis to get its experimental gene therapy against potentially deadly spinal muscular atrophy that is nearing a filing for U.S. approval.
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Cambridge, Massachusetts-based Sarepta is among a clutch of drugmakers trying to develop successful gene therapies that hold promise for people with rare genetic diseases including DMD and spinal muscular atrophy.
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Spinal muscular atrophy, which hits 1 in every 10-11,000 newborns, has been a target of significant interest as drugmakers move into a rare disease area that commands ultra-high prices.
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In a policy reversal, the health insurers Aetna and Anthem will now cover a $2.1 million, one-time treatment for more kids with the rare and devastating disease spinal muscular atrophy.
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But even if he leaves this week, Pruitt will leave behind more than a paper trail of apparent corruption—he'll enjoy a legacy of environmental atrophy that's almost impressive in scope.
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A new drug for spinal muscular atrophy — a genetic disorder that progressively breaks down the patient's muscle tissue, resulting in early death — came on the market in the US in 2017.
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Glasses like the eSight2100 are good for people suffering from any one of about a dozen eye conditions, among them Stargardt disease, optic atrophy, macular degeneration and some forms of glaucoma.
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"AGBRESA allows us to address the issue of muscular atrophy caused by weightlessness," Jennifer Ngo-Anh, Team Leader in Human and Robotic Exploration at the ESA, said in a press statement.
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This is an increasingly common trajectory in extreme music, yet the sincerity and passion with which Downfall of Gaia has grown into its sound are at a clear peak on Atrophy.
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In a YouTube video posted by Valpeoz last year, she reveals she was diagnosed with optic nerve atrophy, which is severe damage to the optic nerve, when she was 10 years old.
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Both Earth and Mars rely on the working class of "Belters" who live on asteroids and suffer extreme poverty, poor air quality, water rations, and muscle underdevelopment and atrophy from low gravity.
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The goal is to take vaginal tissue that has thinned with atrophy and make it thicker with better blood flow, which has the potential to decrease painful intercourse, Pinkerton said by email.
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The continual waves of screams washed away any hope of the band ever hearing themselves onstage, and as a result their performance chops began to atrophy—not that the fans cared much.
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"If we continue to suspend the major exercises, our military capacity will begin to atrophy," said Abraham Denmark, a former deputy assistant secretary of defense for East Asia under President Barack Obama.
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Then, just months after Reese gave birth to the couple's second child, a son named Colton, he was diagnosed with spinal muscular atrophy, a rare genetic disease that affects voluntary muscle movement.
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If he wins, a party built on freedom and internationalism will become entrenched as a party of authoritarianism and isolation, which means that within a few years it will atrophy and die.
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I'd committed rotten crimes and wound up in rotten dwellings with other rotten souls who now floated about, twitching with stimuli for atrophy and nowhere closer to anything in today's remnant society.
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We must prevent the trivia section from expanding into the logic cortex and causing the creativity lobe to atrophy, lest we become deformed hulks, roaming the landscape, muttering factoids to terrified bystanders.
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Most people do not do much exercise while a broken arm is healing and can struggle with this loss of muscle, known as "atrophy," and weakness for many weeks after the injury.
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The Food and Drug Administration has approved the first drug to treat patients with spinal muscular atrophy, a savage disease that, in its most severe form, kills infants before they turn 282.
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About 1 in 10,000 babies are born with spinal muscular atrophy — or about 400 a year in the United States — and it is among the leading genetic causes of death in infants.
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Photo: Leon Neal (Getty Images)People at high risk for Alzheimer's disease may be able to slow down the atrophy of their brains through regular aerobic exercise, a new study has found.
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Multiple sclerosis drug Tecfidera is facing competition from newer treatments such as Roche Holding AG's Ocrevus, and Biogen has been banking on its spinal muscular atrophy treatment, Spinraza, to drive future growth.
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The FDA does not believe that the manipulation impacts the safety or testing surrounding the version of the drug, which treats spinal muscular atrophy (SMA), the leading genetic cause of death in infants.
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Biogen shares rose 2 percent to $523 after the U.S. Food and Drug Administration (FDA) on Friday approved its drug to treat spinal muscular atrophy, the leading genetic cause of death in infants.
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U.S. Senate Finance Committee Chairman Chuck Grassley has asked the Basel-based company to give details on data manipulation on its $2.1 million gene therapy to treat spinal muscular atrophy by Aug. 23.
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The product, known as nusinersen, was developed by Biogen in collaboration with Ionis to treat spinal muscular atrophy, a genetic disease affecting the part of the nervous system that controls voluntary muscle movement.
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"As a global leader in the treatment of spinal muscular atrophy, a life threatening, devastating disease, Biogen welcomes additional therapeutic options to help individuals with this rare disease," Biogen said in a statement.
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Biogen also said it filed its application with U.S. regulators seeking priority review for nusinersen, which would be the first treatment for spinal muscular atrophy, a leading genetic cause of death in infants.
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Cambridge, Massachusetts-based Biogen, which has been trying to develop its promising spinal muscular atrophy and Alzheimer's disease drugs, attracted some takeover interest earlier this year, although it is not pursuing a sale.
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Biogen has also been working on another potential blockbuster drug, known as Spinraza, which could become the first FDA-approved treatment for spinal muscular atrophy, the leading genetic cause of death in infants.
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"Previous studies have shown associations between gray matter atrophy and risk of developing dementia," study author Mark Hamer, a professor of exercise as medicine at Loughborough University in England, wrote in an email.
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Meanwhile, the 42-year-old U.S. doctor spent $8.7 billion on gene therapy company Avexis to get hold of its spinal muscular atrophy treatment that offers hope of a cure for some children.
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We would never again have to weigh the list of possible side effects that accompany insincere tolerance, including frequent anger, compassion atrophy, dizzying spells of dishonesty, instability of character and deep, chronic division.
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"What's happened on the left is a complete atrophy of any kind of alternative thought," says Dan Nexon, an international relations professor at Georgetown who advised Bernie Sanders's presidential campaign on foreign policy.
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This election is not just about who will win the House of Representatives, then—it's about whether American democracy will become more inclusive or atrophy under the weight of bad-faith suppression tactics.
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The Food and Drug Administration on Friday approved a gene therapy for spinal muscular atrophy, a rare muscle-wasting disease that, in its most severe form, kills many babies before they turn 2.
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The company is enrolling patients for two Phase III trials of its high-profile Alzheimer's drug, aducanumab, and has high hopes for an experimental treatment for spinal muscular atrophy in partnership with Ionis Pharmaceuticals.
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"This is the first time in our field where a drug reduced brain atrophy," said Dr. Serge Gauthier, lead researcher of the study and director of the Alzheimer's disease research unit at McGill University.
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Not long after Gloria and Steve Kimmel lost their infant son, Isaac, to spinal muscular atrophy on July 31, 2015, they each got a single angel's wing tattooed on their backs to honor him.
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Biogen shares rose 2 percent to $1500 after the U.S. Food and Drug Administration (FDA) on Friday approved the company's drug to treat spinal muscular atrophy, the leading genetic cause of death in infants.
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The nanoceria have the potential to prevent muscle-wasting in astronauts, and also to work as an anti-aging therapy for elderly people or those with Parkinson's disease and other forms of muscular atrophy.
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The capsule also delivered a group of 20 live mice from the pharmaceutical company Eli Lilly, which will help researchers better understand how muscles atrophy, since muscle tissues waste away much faster in space.
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He also highlighted the second-quarter launch of gene therapy Zolgensma, the world's most expensive drug at $2.1 million per patient, for deadly spinal muscular atrophy (SMA), saying he was pleased with its progress.
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Separately it said its drug risdiplam helped people with type 2 or 3 spinal muscular atrophy improve their motor function, as the Swiss drugmaker presses ahead with a medicine it sees rivalling Biogen's BIIB.
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But even with pharmacy benefit changes, employers are worried about how they're going to pay for new gene therapies coming to market with record prices, like Novartis' $2 million spinal muscular atrophy treatment Zolgensma.
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Dyspareunia is a symptom of vulvar and vaginal atrophy, a condition triggered by the loss of female hormone estrogen after menopause that the company estimates affect about 32 million women in the United States.
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The first two gene therapies to be included in Cigna's program are blindness therapy Luxturna and the most expensive drug in the world Novartis' $2.1 million spinal muscular atrophy treatment, Zolgensma, the insurer said.
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Schwan sees these newer drugs -- combined with late-stage trial hopefuls including for Huntington's disease, lupus and spinal muscular atrophy -- maintaining momentum without forcing him to look beyond Roche's own research departments for help.
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Seperately the U.S. Food and Drugs Administration has granted priority review to its Risdiplam treatment for spinal muscular atrophy The company is buying Romanian mortar and thermal insulation company Adeplast for an undisclosed sum.
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In her tableau, Tahrir Square is but a single inflection point in a long history of national atrophy (the 18 days of the revolt are awkwardly inserted mid-narrative in dated journal-entry format).
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"When we think of 'work' or 'labor,' the idea elicits images of paid work and rigid ideas of employment," said Alice Wong, a disability rights activist and sociologist who lives with spinal muscular atrophy.
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Sales of Spinraza, the first approved treatment for spinal muscular atrophy, rose 26.73 percent to $23.40 million, but fell short of analysts' estimate of $487.9 million, largely due to pricing pressure and dosing schedule.
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On some weekends and days after my school job, I've worked (and continue to work) as an in-home personal care attendant (PCA) for a 229-year-old woman who has spinal muscular atrophy.
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Roche's Spark deal, seen closing in the second quarter, follows Novartis's $8.7 billion purchase of U.S.-based Avexis last year, also to gain a platform of gene therapies for disorders including spinal muscular atrophy.
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The U.S. Food and Drug Administration hasn't approved vaginal laser treatments for what's known as vulvovaginal atrophy, a condition that often accompanies menopause and can include symptoms like vaginal dryness, painful intercourse and urinary incontinence.
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In July, the FDA issued a consumer warning stressing that laser treatments are not approved for vaginal cosmetic procedures or to treat atrophy, and emphasizing that the safety and effectiveness of these treatments is unproven.
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What researchers found was that the people who drank the most had the highest risk of hippocampal atrophy, which is a form of brain damage often associated with memory-loss conditions like Alzheimer's and dementia.
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The FDA said it does not believe that the manipulation impacts the safety or testing surrounding the version of the drug, which treats spinal muscular atrophy (SMA), the leading genetic cause of death in infants.
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ZURICH (Reuters) - Roche's bid to rival Biogen and Novartis in treating spinal muscular atrophy (SMA) got a lift on Monday when the Swiss drugmaker said its drug risdiplam improved motor function in a key study.
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Even though AveXis' lead drug, which treats spinal muscular atrophy, competes with a similar treatment from Biogen, Novartis' faith in the company helped boost shares of AveXis over 81 percent to a 52-week high.
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But rather than go full bore for days of juice-induced brain fog and muscle atrophy from lack of protein, just eat a normal, healthy diet and drink a damn juice every now and again.
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Yi Li Jie, a spinal atrophy patient I met, has to pay out of pocket for her caregivers; she also has to pay a substantial share of her transportation costs to get to medical appointments.
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If I mentioned that I exercised my legs to avoid atrophy so that I may be able to benefit if there was ever a cure for paralysis, I worried over betraying the disability rights cause.
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Their artworks offer a sobering but ultimately optimistic message to visitors: life is little more than a long sequence of sufferings, riddled with malaise, loss, angst, and the inevitable atrophy of the body and mind.
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But it's also because part of what Essential wants to do is change the way people feel about smartphones, and shake up some of the sense of atrophy that has descended on this highly commoditized market.
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In clinical trials, Bausch's treatment was generally well-tolerated with no increase in epidermal atrophy - thinning or depression of skin due to reduction of underlying tissue - when applied once daily for eight weeks, the company said.
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Novartis bought biotech company AveXis for $8.7 billion earlier this year, and executives are thinking about charging at least $4 million for AveXis' highly touted gene therapy to treat spinal muscular atrophy, according to Endpoints News.
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The Swiss drugmaker is expected this year to launch its gene therapy called Zolgensma for spinal muscular atrophy, a muscle-wasting disease and leading genetic cause of infant mortality, affecting one in every 11,000 live births.
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Leerink Partners analyst Geoffrey Porges said Merck, Allergan or other large drugmakers would benefit from acquiring Biogen and its experimental drugs in late-stage trials, which include treatments for Alzheimer's, multiple sclerosis and spinal muscular atrophy.
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Thanks to the stunning atrophy of our collective online memory, you may not remember this as well as you remember J. Law pizza GIFs or Prattkeeping, but Gosling and Stone were Hollywood's OG internet power couple.
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HEAD START Roche's Spark deal, seen closing in the second quarter, follows Novartis's $8.7 billion purchase of U.S.-based Avexis last year, also to gain a platform of gene therapies for disorders including spinal muscular atrophy.
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Why it matters: Given the deteriorating international situation, the likely outlook for U.S. defense spending dims the prospects for Mattis's long-term strategic goals — and for the military's ability to catch up after years of atrophy.
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Initiating a formal criminal investigation would give the Isaias government more reason to retrench into its righteous isolation — a primary cause of poor governance and economic atrophy in Eritrea, which engender abuses in the first place.
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Shane and Hannah Aylward, his new fiancée, are an interabled couple: Shane has a condition called spinal muscular atrophy, a type of muscular dystrophy that means his muscles are incredibly weak, while Hannah is able-bodied.
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First up: Some really important reporting from Emma Court, who spoke with families who are having a hard time getting access to Zolgensma, the $2.1 million treatment for spinal muscular atrophy that was approved in May.
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New drugs that may fall under their scrutiny in the next year include potentially life-saving therapies for spinal muscular atrophy and Duchenne muscular dystrophy as well as oral treatments for migraine, diabetes and multiple sclerosis.
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Spinraza, the first approved treatment for spinal muscular atrophy (SMA) and the company's most important future growth driver, had sales of $468 million for the quarter, exceeding analysts' estimates of $448.1 million, according to Refinitiv data.
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One of the women gave birth to a baby with microcephaly, a defect that has been associated with the virus, and at least one other had an abortion after severe brain atrophy was detected in the fetus.
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Although topical steroids are frequently used for psoriasis, their long-term use have been limited due to serious side effects such as epidermal atrophy, which was seen in Bristol-Myers Squibb's Ultravate after two weeks of treatment.
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MOM WARNS OF VENOMOUS CATERPILLARS AFTER SON&aposS HARROWING MEDICAL SCARE "Because of the large diameter of the macular hole and the accompanying atrophy in this patient, we favored conservative management rather than surgery," the doctors wrote.
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Biogen shares rose 2.25 percent to $294 in light premarket trading after the U.S. Food and Drug Administration (FDA) on Friday approved its drug to treat spinal muscular atrophy, the leading genetic cause of death in infants.
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Without potential future revenue from Alzheimer's, Biogen has poor growth prospects as it faces patent issues over its big-selling multiple sclerosis drug Tecfidera and possible competition to spinal muscular atrophy drug Spinraza, Wall Street analysts said.
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This was a surprise because researchers had expected that calcification might be related to vascular problems common with smoking and diabetes that could contribute to shrinkage of tissue, or atrophy, in the hippocampus and subsequent cognitive decline.
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People want to know whether the City will atrophy; whether Italy will have a debt crisis or itself leave the European Union; whether European banks might enter another downward spiral; whether the euro is in peril again.
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Here are some of the main factors that may affect Swiss stocks: The drugmaker's gene therapy unit Avexis said new data showed positive results of its Zolgensma drug for a broad spectrum of spinal muscular atrophy patients.
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The self-proclaimed Mars geek had interned at NASA's Ames Research Center in California, where she studied how to prevent bone density loss and muscle atrophy in astronauts making the months-long journey to the Red Planet.
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ZURICH/SAN FRANCISCO, Jan 14 (Reuters) - Swiss drugmaker Roche plans to price its oral spinal muscular atrophy drug (SMA) risdiplam aggressively to challenge two of the world's most expensive medicines, Biogen's Spinraza and Novartis's gene therapy Zolgensma.
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NEW YORK (Reuters) - When Malachi Anderson was diagnosed with a rare and often deadly disease called spinal muscular atrophy (SMA) as an infant nearly four years ago, his parents Tina and Torence had a decision to make.
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"Democrats need a short-term play and a long-term play — the long-term play has to be building themselves back up and solving the down-ballot atrophy that's set in over the past decade," Daley says.
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It was demonstrated that people who drank between 15 and 20 standard drinks per week were three times more likely to suffer from hippocampal atrophy—damage to the area of the brain involved in memory and spatial navigation.
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But there is a directive: if you spent, as I did for Green Room, the vast majority of a production in one room, basically there is a desire to not atrophy and just go do something very different.
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ZURICH (Reuters) - Novartis Chief Executive Vas Narasimhan said on Wednesday that the Swiss drugmaker is examining a price range for its Zolgensma gene therapy for spinal muscular atrophy (SMA) of between $1.5 million and $5 million per patient.
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The longer people are out of work, the more their skills and their self-confidence atrophy, the less appealing they look to potential employers and the more likely they are to give up and subsist on the dole.
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ATROPHY After the U.S. Federal Reserve began to run down its $4 trillion plus balance sheet from October 2017, banks' cash reserves at the Fed also contracted, while their holdings of U.S. Treasuries grew rapidly, the BIS said.
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Pfizer's coupons said consumers would "PAY NO MORE THAN" $15, $20 or $25 for Estring to treat vaginal atrophy, Quillivant XR and Quillichew ER for attention deficit hyperactivity disorder, and Flector patches for acute pain from minor injuries.
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In fact, there is some evidence that recessions actually cause lasting damage to a country's economic potential — that they hurt, rather than help — by thrusting people out of the work force unnecessarily and causing their skills to atrophy.
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These cases were not part of a controlled trial designed to prove whether or how vaginal laser treatments might help ease sexual pain or other problems associated with atrophy; they also may not represent what all women would experience.
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BOSTON (Reuters) - Novartis AG's top executive said on Wednesday it expects to price its gene therapy for spinal muscular atrophy "far lower" than the $5.43 million to $5 million figure the Swiss drugmaker has said it could be worth.
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He points out that it was a far bigger game that Shadowrun ever came close to being, and it has an audience that has largely gone hungry ever since, in Weisman's words, Microsoft let it atrophy for a decade.
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Without the potential revenue from an Alzheimer's drug, the company has poor growth prospects as it faces patent issues over its flagship Tecfidera multiple sclerosis drug and possible competition to spinal muscular atrophy drug Spinraza, Wall Street analysts said.
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Of course this could be a challenge as he or she has been out of the loop, removed from active, hands-on control of the system, and can also be suffering from lack of situational awareness and skill atrophy.
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That's because gynecologists may be more knowledgeable about what's known as vulvovaginal atrophy, a common but often overlooked condition that can seriously impact women's lives after menopause and lead to avoidance of intimacy, loss of libido, and painful sex.
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The Swiss drugmaker's assessment of AVXS-101's value for treating spinal muscular atrophy (SMA) has put the company front-and-center in the debate over what "super drugs", for rare diseases afflicting relatively few patients, are really worth.
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He said he recently sought and received prior authorization from a medical insurer for $60,000 to cover multiple implants and other costs for a woman whose dental woes stemmed from severe atrophy of the jaw and other medical problems.
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The Swiss drugmaker's gene therapy Zolgensma, the world's costliest one-time treatment at $4323 million per patient, won Japanese approval to be used to treat patients under the age of two who have the genetic disease spinal muscular atrophy.
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ZURICH, Nov 25 (Reuters) - Roche expects its risdiplam medicine for spinal muscular atrophy to get U.S. approval by next May, the Swiss drugmaker said on Monday, as it takes on Novartis and Biogen in the lucrative rare disease area.
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Whether our criminal justice system is centered on fairness, safety, rehabilitation, punishment, or some other goal, solitary confinement yields the opposite, fostering injustice, violence, mental and physical atrophy, and a lifetime of pain for anyone who interacts with it.
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But don't forget the fact that a number of countries have let their military atrophy while hanging out under the umbrella of US security guarantees, and may not be up to the task when things really hit the fan.
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Without that tissue, the light-sensing cells it supports atrophy and die, making it impossible to get a clear picture of anything straight ahead of you—like, say, the faces of your loved ones or anything past your steering wheel.
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"My gut instinct is that we'll get dumber in some ways — on the principle of muscle atrophy — even as we process vastly more information," says Darrin McMahon, a history professor at Dartmouth College who has written books about the Enlightenment.
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ZURICH/NEW YORK, (Reuters) - Swiss drugmaker Novartis on Friday won U.S. approval for its gene therapy Zolgensma for spinal muscular atrophy (SMA), the leading genetic cause of death in infants, and priced the one-time treatment at a record $22.2 million.
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What they noted was that the people who drank the most had the highest risk of hippocampal atrophy, a form of brain damage that can impact spatial navigation and can be associated with memory-loss conditions like Alzheimer's and dementia.
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ZURICH, May 8 (Reuters) - Novartis is confident it has adequate production capacity for its Zolsgensma gene therapy should regulators this month approve the drug for multiple forms of the genetic disease spinal muscular atrophy, the Swiss drugmaker said on Wednesday.
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In San Francisco, Alice Wong's parents turn her at night to prevent bedsores and work with aides hired by Ms. Wong to provide much of the near-total care she needs because of a progressive nerve disorder, spinal muscular atrophy.
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The Mayflower Group also concluded that we have to make clear to our fellow citizens that confrontation is not cost-free; If we let arms control agreements atrophy or even disappear, are we willing to pay for an arms race?
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Narasimhan is now counting on AveXis's main drug, AVXS-101 for deadly spinal muscular atrophy (SMA), as well as the Illinois-based company's gene therapy expertise and manufacturing capabilities, to bolster Novartis's neuroscience business, a focus for the Swiss company.
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In a new study from the American Consumer Institute, my coauthors and I compare the costs of conventional treatments for two serious genetic diseases — severe hemophilia and spinal muscular atrophy — with the cost of a one-time gene therapy cure.
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Former President Barack Obama oversaw the atrophy of the Democratic Party at the state and local level -- a result of the party's failure to turn out its voters in non-presidential elections that led to losing about 1,000 state legislative seats.
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Thirty years of muscular atrophy have left them as stretched and sinewy as fine silverwork, and with only the slightest motor control, he tends to hold them perfectly flat, gesturing this way and that with all five fingers at once.
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But Wall Street's focus has shifted to Biogen's newer growth driver Spinraza, a treatment for a rare, often fatal muscular disorder called spinal muscular atrophy (SMA), particularly in light of the recent failure of Biogen's leading experimental Alzheimer's disease treatment.
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For the study, researchers asked 90 primary care providers and 29 gynecologists multiple choice questions about how to recognize vulvovaginal atrophy and surveyed participants about how often they assessed patients for these issues and what barriers stopped them from doing this.
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Perhaps most important is a third possible explanation involving brain structure; hearing loss results in a faster rate of brain atrophy mostly over the hearing portion of the brain, which is also involved in functions like memory, learning and thinking.
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"Teens, Wall Street guys, guys camped out with a shopping cart, a pizza place is the most diverse space in the city," said Colin Atrophy Hagendorf, author of "Slice Harvester: A Memoir in Pizza" and host of the Radio Harvester podcast.
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Instead the political abdication of the Congress, the steady atrophy of legislative power and flight from legislative responsibility, means that America is increasingly governed by negotiations between the imperial presidency and whichever philosopher-king has the swing vote on the court.
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For identifying TDP43 as a key protein aggregating in the cytoplasm in frontotemporal lobular dementia and amyotrophic lateral sclerosis, and for capitalizing on the toxicity of alpha-synuclein to gain insight into cellular drivers of Parkinson's disease and multiple system atrophy.
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After excluding cases of dementia and stroke, they also found a possible reason for the declining scores: The M.R.I. results showed that increased exposure to PM 2.5 was associated with increased brain atrophy, even before clinical symptoms of dementia had appeared.
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ZURICH, Dec 5 (Reuters) - Novartis research head Jay Bradner said on Thursday the Swiss drugmaker is focusing drug development efforts against spinal muscular atrophy on gene therapy Zolgensma and retreating from oral therapy like its molecule LMI070, also called branaplam.
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The condition J.J. has, Duchenne muscular dystrophy, is a rare genetic disorder that, beginning in early childhood, causes progressive atrophy and weakening of muscles, making it difficult for those affected to run, walk, sit and, eventually, breathe, leading to early death.
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The extremely expensive drug, the first approved treatment for the rare, often fatal spinal muscular atrophy (SMA), is seen as the most important new growth driver for Biogen, with analysts forecasting eventual annual sales between $21 billion and $2 billion.
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People who drank more than 30 units a week on average had the highest risk, but even those who drank moderately - between 14 and 21 units a week - were far more likely than abstainers to have hippocampal atrophy, the scientists said.
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Barack Obama has come under fire for letting the party give up on the "50-state strategy" and allowing the Democratic National Committee to atrophy, which likely helped Republicans seize so many state offices that they have complete power in 26 states.
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While this may sound like a boon, it turns out it can have some pretty negative side effects, like a 20 percent reduction in blood volume, which in turn can cause the heart to atrophy because it has less blood to pump.
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Zolgensma was approved in late May as a one-time treatment for spinal muscular atrophy (SMA), the leading genetic cause of death in infants.. The disease often leads to paralysis, breathing difficulty and death within months for babies born with the disease.
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LOS ANGELES/ZURICH (Reuters) - Novartis AG is offering price discounts in negotiations with U.S. health insurers on its gene therapy for spinal muscular atrophy (SMA), a treatment that could cost more than a million dollars, but the gesture comes with strings attached.
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Here are some of the main factors that may affect Swiss stocks: * Novartis is offering price discounts in negotiations with U.S. health insurers on its gene therapy for spinal muscular atrophy (SMA), a treatment that could cost more than a million dollars.
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ZURICH, Nov 11 (Reuters) - Roche said on Monday its drug risdiplam helped people with type 2 or 3 spinal muscular atrophy improve their motor function, as the Swiss drugmaker presses ahead with a medicine it sees rivaling Biogen's Spinraza and Novartis's Zolgensma.
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Novartis said on Monday it plans to buy AveXis for $218 per share in a cash deal totaling $8.7 billion, adding a therapy hopeful for spinal muscular atrophy (SMA) to the Swiss drugmaker's pipeline that is expected to reap billions in annual sales.
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Access challenges could eventually get resolved but 'there are people stuck in the middle'Patients also had a hard time getting the other spinal muscular atrophy drug, Spinraza, when it first came out, though those challenges have largely been resolved, Johns Hopkins' Crawford said.
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Just as psychological studies show that infants need emotional mirroring and a caregiver's facial responsiveness for optimal brain development, socialization, and wellness, so to do we atrophy as adults when we lack this -- what is essentially empathy -- in our day-to-day existence.
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It called out Novartis's $475,000 cancer cell therapy Kymriah and its still-unapproved gene therapy for spinal muscular atrophy that Novartis contends is cost-effective at $4-$5 million per patient, while independent groups have concluded its value is less than that.
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At Novartis, Tschudin takes over a main drugs business with $35 billion in annual sales and a stable of medicines including newly approved $2.1 million-per-patient gene therapy Zolgensma, the world's most expensive one-time therapy, for children with spinal muscular atrophy.
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" Therapy hailed as a 'milestone' for genetic disorder In May, the FDA's acting commissioner, Dr. Ned Sharpless, called the spinal muscular atrophy therapy's approval "another milestone in the transformational power of gene and cell therapies to treat a wide range of diseases.
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"As you know, we've pivoted to developing Zolgensma as definitive therapy for spinal muscular atrophy and don't see a big opportunity for oral therapy there, or we would develop this molecule further," Bradner said at an analyst and investor event in London.
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When Dr. Hirano traveled to London this month to examine Charlie, about six months after he had first been invited, a series of scans showed that the boy had suffered muscular atrophy, that the damage was irreversible and that treatment would be futile.
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NEW MEDICINES At Novartis, Tschudin takes over a main drugs business with $35 billion in annual sales and a stable of medicines including newly approved $2.1 million-per-patient gene therapy Zolgensma, the world's most expensive one-time therapy, for children with spinal muscular atrophy.
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Instead, any atrophy will instead make itself known when we're struggling to remember a very common word, getting hopelessly lost in a part of town we're intimately familiar with, or being driven to tears trying to figure out how to set up a personal hotspot.
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Astronauts, for example, routinely spend two hours a day exercising on equipment designed to mitigate muscle atrophy and bone loss caused by low gravity, but they still return to Earth after a six-month space-station stint with mild osteoporosis and significantly weakened muscles.
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Yet, it is clear that a continued lack of investment will result in a generational atrophy that would take the nation decades to rebuild—leaving America extremely vulnerable at a time when other nations are making significant investments in international studies and world area expertise.
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As exploitative and tacky as Rizin can be, they put on some entertaining fights and they actually displayed some fresh, exciting Japanese prospects in a country which has been hurting for young talent since the MMA scene began to atrophy in the years after PRIDE.
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But then I realised that this first impression was simply an effect of alienation, a primitive, instinctual rejection on my part of the unfamiliar, and that it was this very jolt to complacency and atrophy and idées reçues that the artists wanted to deliver.
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Yi Jie Li, a 25-year-old woman with spinal atrophy and an outspoken advocate who wrote the 2017 book 103,300 Days: The Most Ordinary Luxury, penned a letter to the NHIA pleading with it to cover the drug for the patients it could help.
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Concern over this atrophy is what is prompting so many Democratic officials — including Mr. Obama himself and Eric H. Holder Jr., his former attorney general — to urge donors and activists to direct their time and money toward unglamorous causes such as redistricting and statehouse races.
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In a 30-year study that looked at the brains of 5503 middle-aged heavy drinkers, moderate drinkers and teetotallers, the researchers found people drank more alcohol had a greater risk of hippocampal atrophy - a form of brain damage that affects memory and spatial navigation.
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He also said that after Mr. DeRisi was arrested in 2015 and accused of threatening a lawyer for a homeowners' association with which he had a dispute, a psychological evaluation found that Mr. DeRisi had cerebral atrophy that seemed to be affecting his actions.
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Abbie's commitment to the atrophy of his body is an initial source of absurdist comedy, but as the film continues and his body is further emaciated and deteriorated, Burge's performance becomes increasingly harrowing in its abject physicality, less Napoleon Dynamite and more David Cronenberg.
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Zolgensma was approved in late May as a one-time treatment for spinal muscular atrophy (SMA), the leading genetic cause of death in infants.. The disease often leads to paralysis, breathing difficulty and death within months for babies born with the most serious Type I form.
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She says paralyzing the muscles in your brow or around your eyes will, over time, cause them to atrophy (that's the medical term for when a muscle withers from underuse — think what an arm looks like when you have a cast removed after a broken bone).
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You've got shades of The Matrix, where people's bodies atrophy while they're living in a machine-constructed dreamworld; of the zombie-like VR junkies in Shadowrun; and of every other movie, book, and video game about people ruining their real-world lives to enjoy a virtual one.
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"We badly need a nonsteroidal topical that can get around serious steroid concerns and this drug showed no skin atrophy or other significant side effects," said Dr. Lawrence Eichenfield of the University of California San Diego and lead author of American Academy of Dermatology eczema treatment guidelines.
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ZURICH (Reuters) - A drug being co-developed by Roche to treat spinal muscular atrophy (SMA) helped improve development scores in babies with the genetic disease, a study released on Monday showed, as the race heats up for therapies destined to be among the drug industry's most expensive.
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Haven't you heard that it's getting hotter because of this tilt, this ever-increasing tilt of the earth, which was inevitable and not humanity's fault, not our cars or our emissions or Aqua Net but plain and simple entropy—or was it atrophy, or was it apathy?
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The larger and more established ones, such as the Alzheimer's Association, Michael J. Fox Foundation and the Spinal Muscular Atrophy Foundation, are investing millions not only in the search for specific cures but also for the biological tools and biomarkers any researcher or company could use.
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By the time many of us are in our mid to late 50s, portions of our heart muscle have begun to atrophy and weaken, and our major cardiac arteries — the blood vessels that move blood from our hearts and to the rest of the body — have stiffened.
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