63 Sentences With "antagonistically" | Random Sentence Generator

It really surprises me, actually, the degree to which publications frame themselves antagonistically to this president.

"People keep underestimating insurgent candidates, particularly first-time candidates," said Nixon, who is running antagonistically to Cuomo's left.

"As long as she does not view us antagonistically, which I hope she doesn't, I'm personally very excited about it," he said.

There's some evidence that Lithium and cocaine react antagonistically, so you could be working against your medication's effectiveness without even getting high for your trouble.

The missile passed over the northern island of Hokkaido where anxious residents told local media they didn't understand why North Korea was acting so antagonistically.

With regard to Iran, which Mr. Trump has spoken of antagonistically, he suggested that should the country harass a United States vessel, he would respond with force.

A little more than 30 days since the inauguration, the administration still has 2,000 vacancies, many of which require Senate confirmation, a process which is antagonistically slow and politically charged.

Curiously, both the AI model and the real C. elegans neural circuit contained two neurons that seemed to be acting antagonistically, he said—when one was highly active, the other wasn't.

The video, posted Wednesday, first pointed out by electric vehicle blog Electrek, is a stab at generating hype around Tesla's brand days after CEO Elon Musk behaved antagonistically toward Wall Street analysts during the company's first-quarter earnings conference call.

For its intermissionless 85 minutes, "Funny Thing" abides by the rom-com rules that a couple who meet antagonistically have to be attracted to each other, and that any heroine who is so aggressively defensive has a tortured back story, preferably involving a mirror-image parent.

And under the dark, club-like lighting, their hyper-theatrical walks—some hunched over, others dragging bags behind them like pets, another on his iPhone the whole time—suggested a beautifully, antagonistically free mode of being in the world amidst and even through the traditionally institutional realms of merchandise, sports, and business.

The more tribalized the world is—the more antagonistically divided along national, ethnic, religious, ideological lines—the more danger there is in, for example, letting arms control challenges go unaddressed: The more nations will be in the mood to lob missiles, the more terrorist groups there will be that might get ahold of a nuke or a bioweapon.

That adviser could have argued that for an administration looking to manage great-power competition, it is patently illogical to elevate a regional spoiler to great-power status, antagonistically martyr one of its leaders, gratuitously invigorate nonstate militants, and set the United States on a path toward war in a region it had hoped to calm.

Long neurotoxin 1 (LNTX-1) is a neurotoxin that binds antagonistically to all types of muscular and neuronal nicotinic acetylcholine receptors. LNTX-1 is found in the venom of the king cobra (Ophioophagus hannah).

To circumvent this problem, MerD also binds to MerO in order to act antagonistically to Hg2+ bound MerR. MerD is produced when MerR is active with Hg2+ since MerD is encoded in the structural mer genes.

Watanabe has said that Spike has a habit of being very indirect with his emotions; for example, he may behave antagonistically towards someone he actually likes. Watanabe says that Spike's relationship with Faye Valentine is a prime example of this tendency.

Mipartoxin-I is proposed to bind antagonistically to the nicotinic acetylcholine receptors and consequently inhibit the activity of this receptor without damaging the muscle fibres. The toxin blocks the muscle contractions without interfering with presynaptic acetylcholine release, indicating that it acts post-synaptically.

Constricted blood vessel. Arteries—and veins to a degree—can regulate their inner diameter by contraction of the muscular layer. This changes the blood flow to downstream organs, and is determined by the autonomic nervous system. Vasodilation and vasoconstriction are also used antagonistically as methods of thermoregulation.

Stefan Bekowsky (Sean McGowan) is the partner of Cole Phelps while on the Traffic Desk. Bekowsky was partnered with Phelps following the latter's promotion from the Patrol department. While their relationship began antagonistically, they soon became close. Bekowsky helped Phelps to investigate and solve many crimes, uncovering acts of conspiracies, fraud and murder.

She instructs Katharine that she will need new dresses for Commencement and trusts her mother to supply them. Mrs. Comstock, always antagonistically honest, presents her with an old dress. Elnora considers this an unforgivable betrayal, a sign of her mother's disregard and lack of love for her. That night, Elnora must find a good dress elsewhere.

The endocrine precursors are a committed group of progenitors that develop into all of the endocrine cells in the pancreas. Endocrine lineages develop into Delta cells, PP-cells, Epsilon cells, Beta cells and Alpha cells. Alpha cells produce glucagon and beta cells produce insulin. Insulin and glucagon antagonistically regulate the glucose homeostasis in the mammalian body.

Dopamine beta (β)-hydroxylase deficiency is a condition that affects the autonomic nervous system (ANS). The ANS works via two opposing branches, the sympathetic and parasympathetic, both of which antagonistically control involuntary processes that regulate bodily homeostasis. Problems related to DβH deficiency often first appear as complications shortly after birth. Postnatal episodes may include vomiting, dehydration, hypotension, muscle hypotonia, hypothermia, and hypoglycemia.

Sound is mainly produced when the fish are interacting antagonistically or courting. Each species of Trichopsis has its own patterns of producing sounds. These fishes may be able to settle antagonistic interactions as they can use the sounds produced to assess the condition and fitness of nearby fishes. Females produce a ‘purring’ sounds when initiating spawning, and in this aspect they are unique among fishes.

A very common iatrogenic effect is caused by drug interaction, i.e., when pharmacotherapists fail to check for all medications a patient is taking and prescribe new ones that interact agonistically or antagonistically (thereby potentiating or attenuating the intended therapeutic effect). Such situations can cause significant morbidity and mortality. Adverse reactions, such as allergic reactions to drugs, even when unexpected by pharmacotherapists, are also classified as iatrogenic.

Hypertension can also be caused by Insulin resistance and/or hyperinsulinemia, which are components of syndrome X, or the metabolic syndrome. Insulin is a polypeptide hormone secreted by cells in the islets of Langerhans, which are contained throughout the pancreas. Its main purpose is to regulate the levels of glucose in the body antagonistically with glucagon through negative feedback loops. Insulin also exhibits vasodilatory properties.

This gene encodes a protein that lacks the normal DNA-binding domain contained in other nuclear receptors. The encoded protein acts as a dominant- negative regulator of transcription of other nuclear receptors including steroidogenic factor 1. This protein also functions as an anti-testis gene by acting antagonistically to SRY. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

Justin and Edina put up with each other for Saffron's sake but are not always successful in carrying out this charade. At times Edina seems to be extremely bitter over the dissolution of their marriage, and she is also jealous of the warm relationship he shares with Saffron. Patsy and Justin have a variable relationship. They often act antagonistically toward each other, but other times seem to get along well.

Patrice Serxner (played by Sonya Walger) is the FBI agent who takes over Fuller's position after he is killed. Initially Darwyn acts antagonistically towards her due to her replacing Ray and her cold attitude. They later develop a friendship once she is shown to be just as capable as Ray and can look after Darwyn just as well. She has a brother in the military who she cares about.

Although there are so many negative effects related to genes that are antagonistically pleiotropic, it is still present among most forms of life. Indeed, pleiotropy is one of the most common traits possessed by genes overall. In addition to that, pleiotropy is under strong stabilizing selection. In one experiment with mice and the morphology of the mandible, 1/5 of the loci had effects of pleiotropy for the entire mandible.

Conversely, inhibiting Smad2 in kidney cells (full Smad2 knockouts are embryonic lethal) actually leads to more severe fibrosis, suggesting that Smad2 works antagonistically to Smad3 in the progression of renal fibrosis. Unlike the R-Smads, Smad7 protein is typically under-expressed in diseased kidney cells. This loss of TGF-B inhibition results in increased amounts of active Smad2/3, which contribute to the progression of renal fibrosis as described above.

In response to DNA damage, ATG5 expression is upregulated, increasing autophagy, preventing caspase activation and apoptosis. ATG5 is also responsible for G2/M arrest and mitotic catastrophe by leading to the phosphorylation of CDK1 and CHEK2, two important regulators of cell cycle arrest. Furthermore, ATG5 is capable of translocating to the nucleus and interacting with survivin to disturb chromosome segregation by antagonistically competing with the ligand Aurora B.

Exposure to antiandrogens can occur unintentionally due to natural or anthropogenic compounds in the environment. Environmental compounds affecting the endocrine system, termed endocrine disruptors, that antagonistically affect androgen receptors and androgen production can negatively affect animals that come in contact with the compounds as well as their future generations. Certain pesticides and insecticides as well as industrial chemicals possess antiandrogen properties. Some species of plants produce phytochemicals with antiandrogenic effects.

The binding of GTP to the GTPase results in the release of the GEF, which can then activate a new GTPase. Thus, GEFs both destabilize the GTPase interaction with GDP and stabilize the nucleotide-free GTPase until a GTP molecule binds to it. GAPs (GTPase-activating protein) act antagonistically to inactivate GTPases by increasing their intrinsic rate of GTP hydrolysis. GDP remains bound to the inactive GTPase until a GEF binds and stimulates its release.

Zenazocine (INN; WIN-42,964) is an opioid analgesic of the benzomorphan family which made it to phase II clinical trials before development was ultimately halted and it was never marketed. It acts as a partial agonist of the μ- and δ-opioid receptors, with less intrinsic activity at the former receptor and more at the latter receptor (hence, it behaves more antagonistically at the former and more agonistically at the latter), and produces antinociceptive effects in animal studies.

Besides the Hippo pathway, Pan also contributed to the understanding of other developmental signaling pathways. As a postdoctoral fellow, Pan identified cAMP-dependent protein kinase (PKA) as a mediator of Hedgehog signalingPan, D., and Rubin, G.M. (1995). cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs. Cell 80, 543-552. and Kuzbanian (ADAM10) as a transmembrane metalloprotease responsible for the proteolytic cleavage and activation of the cell-surface receptor Notch.

A mutation in the signaling pathway PI3K-AKT-mTOR is a factor in the formation of tumors found predominantly on skin, internal organs, and secondary lymph nodes (Kaposi sarcoma). IGF-1R allows the activation of these signaling pathways and subsequently regulates the cellular longevity and metabolic re-uptake of biogenic substances. A therapeutic approach targeting towards the reduction of such tumor collections could be induced by ganitumab. Ganitumab is a monoclonal antibody (mAb) directed antagonistically against IGF-1R.

Fetal and aged mice with this pathophysiological condition have shown a decrease in the activity of calcineurin, the major phosphatase for Elk1. These mice also have age-dependent changes in ERK activation. Moreover, expression of SUMO3, which represses Elk1 activity, increases in the adult Down syndrome patient. Therefore, Down syndrome is correlated with changes in ERK, calcineurin, and SUMO pathways, all of which act antagonistically on Elk1 activity. Elk1 also interacts with BRCA1 splice variants, namely BRCA1a and BRCA1b.

Barts (Alex Spencer), Yorkie (Stephen Huszar), Sholtzy (Andrew Hinkson), Fisky (Jordan Johnson-Hinds), and Boomtown (Boomer Phillips) are five hockey players on the Letterkenny Irish senior team. They're known to speak in sequence, calling on the next one by name. Barts often completes sentences with "you little bitch," punctuated with Sholtzy adding "pussy." They first respond antagonistically to Reilly and Jonesy, but later the five grow to respect them after they start taking the game more seriously.

These related molecules have novel functions and influence diverse biological processes. There is also cross-regulation between the various conjugation pathways, since some proteins can become modified by more than one UBL, and sometimes even at the same lysine residue. For instance, SUMO modification often acts antagonistically to that of ubiquitination and serves to stabilize protein substrates. Proteins conjugated to UBLs are typically not targeted for degradation by the proteasome but rather function in diverse regulatory activities.

Researches on the Danube and the Adriatic; Or Contributions to the Modern History of Hungary and Transylvania, Dalmatia and Croatia, Servia and Bulgaria, Brockhaus Slavs settled along the coast in the 7th century. The Slavs named their settlement Dubrovnik. The Romance ("Latin") and Slavs held each other antagonistically, though by the 12th century the two settlements had merged. The channel that divided the city was filled, creating the present-day main street (the Stradun) which became the city centre.

All symbionts within a plant host interact, often in unpredictable ways. A 2010 meta-analysis indicated that plants colonized by both AM fungi and vertically transmitted endophytes often are larger than plants independently colonized by these symbionts. However, this relationship is context-dependent as AM fungi can interact synergistically with fungal endophytes inhabiting the leaves of their host plant, or antagonistically. Similar ranges of interactions can occur between AM fungi and ectomycorrhizal fungi and dark septate endophytes.

For the majority of the investigated insect species it has been documented that juvenile hormone stimulates the transcription of the vitellogenin genes and the consequent control of vitellogenin production (cf. Engelmann, 1983; Wyatt and Davey, 1996). The vitellogenin expression is part of a regulatory feedback loop that enables vitellogenin and juvenile hormone to mutually suppress each other. Vitellogenin and juvenile hormone likely work antagonistically in the honey bee to regulate the honey bees development and behavior.

Interviewed before the concert, he was antagonistically critical of Cantopop music, saying: "Hong Kong only has entertainment, it has no music. Out of the "Four Heavenly Kings" only Zhang Xueyou (Jacky Cheung) can be considered a singer, the rest are all clowns". In response Jacky Cheung is said to have retorted: "Mainland musicians all live in caves." The death of Tang Dynasty bass guitarist Zhang Ju (张炬), one of He Yong's best friends, on 11 May 1995 affected him in a terrible way.

Furthermore, we have gathered that cytokinins also play a crucial role. This is interesting because cytokinin works antagonistically with auxin, which is a significant part of the gravitropic response pathway. The cytokinins cause the degradation of the auxin transporting PIN1 proteins, which prevents auxin from accumulating in the desired areas for gravitropic bending. This leads us to believe that hydrotropic response can counteract the gravitropic desire to move toward the center of the Earth and allows root systems to spread toward higher water potentials.

When questioned as to why she had restored the former villain, Washū responded that "cute characters don't grow on trees", implying that this was done largely on a whim. This was supported by the fact that she installed a very powerful self-destruct device in Tama- chan because "it seemed amusing". Tama-chan generally got along well with the other members of the Masaki household, but behaved antagonistically toward Ryōko, seeming to mimic Ryōko's own behavior toward Ayeka. Ryōko challenged Tama-chan to a fight, with the loser being required to leave forever.

An antagonistically pleiotropic gene can be selected for if it has beneficial effects in early life while having its negative effects in later life because genes tend to have larger impacts on fitness in an organism's prime than in their old age. An example of this is testosterone levels in male humans. Higher levels of this hormone lead to increased fitness in early life, while causing decreased fitness in later life due to a higher risk for prostate cancer. This is an example of antagonistic pleiotropy being an explanation for senescence.

IGF-1R allows the activation of these signaling pathways and subsequently regulates the cellular longevity and metabolic re-uptake of biogenic substances. A therapeutic approach targeting towards the reduction of such tumor collections could be induced by ganitumab. Ganitumab is a monoclonal antibody (mAb) directed antagonistically against IGF-1R. Ganitumab binds to IGF-1R, preventing binding of IGF-1 and the subsequent triggering of the PI3K-mTOR signaling pathway; inhibition of this pro-survival pathway may result in the inhibition of tumor cell expansion and the induction of tumor cell apoptosis.

During the actual meeting with Barney, Jerry attempted to impress him but failed miserably. The gang reveals that Barney's intervention is about seeing his father, who lives in the same area as Ted's house. Barney reluctantly agrees to have dinner with Jerry's family and meets Jerry's wife, Cheryl, and his son JJ. Barney acts antagonistically toward JJ until he learns that JJ stands for Jerome Junior. Upset, Barney abruptly leaves and Jerry follows him to the garage, where Barney is attempting to steal the basketball hoop attached to it.

The nAChR is unable to bind ACh when bound to any of the snake venom α-neurotoxins. These α-neurotoxins antagonistically bind tightly and noncovalently to nAChRs of skeletal muscles and in neurons, thereby blocking the action of ACh at the postsynaptic membrane, inhibiting ion flow and leading to paralysis and death. The nAChR contains two binding sites for snake venom neurotoxins. Progress towards discovering the dynamics of binding action of these sites has proved difficult, although recent studies using normal mode dynamics have aided in predicting the nature of both the binding mechanisms of snake toxins and of ACh to nAChRs.

This conflict manifests itself in many traits associated with sexual reproduction. Genes expressed in only one sex are selectively neutral in the other sex; male- and female-linked genes can therefore be acted upon separated by selection and will evolve semi-autonomously. Thus, one sex of a species may evolve to better itself rather than better the species as a whole, sometimes with negative results for the opposite sex: loci will antagonistically coevolve to enhance male reproductive success at females’ expense on the one hand, and to enhance female resistance to male coercion on the other.Trivers, R.L. 1972.

Psihologija u Svetu, 7, 29–45. With regard to aggression, on the basis of experimental findings, Konečni distinguished among physical, verbal, play, fantasy and other types of aggression, and proposed the existence of bidirectional causation (behavioral and psychophysiological) between the degree of anger (high arousal antagonistically labeled) and the amount of expressed physical aggression. This theoretical model, which emphasized previously unacknowledged feedback loops, seems to resolve the classical issue of "catharsis". By means of definitional clarity and experimental precision, the model shifts the debate to the many implications of the theoretically sound and empirically observable "cathartic effect",Baron, R.A. (1977).

As a function of empire, a settler colony is an economic means for profitably disposing of two demographic groups: (i) the colonists (surplus population of the motherland) and (ii) the colonised (the subaltern native to be exploited) who antagonistically define and represent the Other as separate and apart from the colonial Self. See: Burmese Days (1934), by George Orwell Othering establishes unequal relationships of power between the colonised natives and the colonisers, who believe themselves essentially superior to the natives whom they othered into racial inferiority, as the non- white Other."Colonialism", Dictionary of Human Geography, pp. 94–98. Retrieved 2 February 2016.

Calhoun antagonistically questions Alex, who asserts the man was a drunk, and suggests he and Patricia robbed the man. While discussing the case of the missing Manfred, Calhoun's colleague tells him about the history of the London Underground, particularly the Victorian railway workers who constructed the tunnels under dire conditions, and an urban legend that a group of descendants who survived an 1892 cave-in still live below ground in an abandoned section of the tunnels. Meanwhile, one of the last surviving members of a family of these railway workers watches his female companion die; they have survived in the underground by resorting to cannibalism of the railway patrons. In an empty chamber, Manfred's body lies, mutilated.

Importantly for Klf4 and Klf5, the amino acids that are predicted to interact with DNA are identical and the two compete for the same CACCC element or GC-rich sequence of the gene promoter region to regulate cell proliferation or differentiation-elated gene expression. Klf4 and Klf5 can act antagonistically during cellular proliferation, differentiation, and promoter activation, either via direct competition or via alterations in their own gene expression. The expression of Klf4 in terminally differentiated, post-mitotic intestinal epithelial cells as opposed to proliferating crypt cells which contain high levels of Klf5 is one example of such opposing effects. Klf4 inhibits proliferation through activation of p21Cip1/Waf1, and direct suppression of cyclin D1 and cyclin B1 gene expression.

Luther's 1543 pamphlet On the Jews and Their Lies Martin Luther, an Augustinian monk and an ecclesiastical reformer whose teachings inspired the Protestant Reformation, wrote antagonistically about Jews in his book On the Jews and their Lies, which describes the Jews in extremely harsh terms, excoriates them, and provides detailed recommendations for a pogrom against them and their permanent oppression and/or expulsion. At one point in On the Jews and Their Lies, Martin Luther goes even as far to write "that we are at fault in not slaying them." According to Paul Johnson, it "may be termed the first work of modern anti-Semitism, and a giant step forward on the road to the Holocaust."Johnson, Paul.

Antagonistic pleiotropy is one of the several reasons evolutionary biologists give for organisms never being able to reach perfection through natural selection. Antagonistically pleiotropic genes are the explanation for fitness trade-offs. This means that genes that are pleiotropic control for some beneficial traits and some detrimental traits; thus, if they happen to persist through natural selection, this will prevent organisms from reaching perfection because if they possess the benefits of the gene, they must also possess the imperfections or faults. An example of this would be female rodents that live in a nest with other females and may end up feeding young that are not theirs due to their intense parental drive.

Mirazón Lahr argues that this challenges our views of what are the causes of conflict; while it is possible that human prehistoric societies simply responded antagonistically to chance encounters with other groups, she believes that the event preserved at Nataruk was a deliberate attack by one group of hunter-gatherers on another. The evidence from Nataruk shows that the attacking party was carrying weapons that would not normally be carried while hunting and fishing. The lesions show that clubs of at least two sizes were used, indicating that more than one of the attackers were carrying them. The attack combined distance (arrows) and close- proximity (melee) weaponry (clubs, stone knives), suggesting premeditation and planning.

These findings supports the idea that the senescence response is antagonistically pleiotropic, or that the response can be simultaneously beneficial and harmful to an organism's fitness. While the senescence response can be effective at protecting organisms from cancer at young ages, it can also cause the age-related decline in tissue function typical of many degenerative diseases in mammals. If the senescence response allowed an organism to be more likely to reach reproducing age while also being deleterious to the organism later in life, there would be little selective pressure to eliminate the harmful effects of the trait. This important concept may explain the development of aging in mammals from an evolutionary perspective.

This is why misexpression of Cerberus can cause the heart to fold in the opposite direction during development. When Cerberus is “knocked down” and BMP and Wnt are up regulated the head does not form. Other experiments using mice that this gene has been “knocked out” showed no head defects, which suggest that it is the combination of the up regulation of BMP and Wnt along with the absence of Cerberus that causes this defect. For the heart, Cerberus is one of several factors that inhibits Nodal to initiate cardiomyogenic differentiation The Cerberus gene family produces many different signal proteins that are antagonistically involved in establishing anterior-posterior patterning and left-right patterning in vertebrate embryos.

Structure of alpha-bungarotoxin (blue) in complex with the alpha-9 nAChR subunit (orange), showing interactions with loops I and II. α-neurotoxins antagonistically bind irreversibly to nAChRs of skeletal muscles, thereby blocking the action of ACh at the postsynaptic membrane, inhibiting ion flow and leading to paralysis. nAChRs contain two binding sites for snake venom neurotoxins. The observation that a single molecule of the toxin suffices to inhibit channel opening is in agreement with experimental data on the amount of toxin per receptor. Some computational studies of the mechanism of inhibition using normal mode dynamics suggest that a twist-like motion caused by ACh binding may be responsible for pore opening, and that this motion is inhibited by toxin binding.

Tobacco Farming In the early 1700s, tobacco smoking was introduced to the north dwelling indigenous communities through the visitation of the Indonesian fishermen. However, the British customs and behaviour of the utilisation of tobacco was introduced into the Australian culture in 1788, due to the colonisation of Australia by the Europeans, and evidently, these tobacco related behaviours rapidly spread throughout the Aboriginal community, the free settlers and the convicts from Britain. When first introduced within Australia, the supply of tobacco was restricted within the Australian community, however by the 1800s tobacco was a fundamental item being used as a reward for a servants labour, or antagonistically used as a punishment for convicts, due to its addictive side effects. Eventually, by 1819, 80 to 90 percent of the labour force were smokers.

This often occurs when patients fail to inform their physician and pharmacist of all the medications they are taking, including herbal and dietary supplements. The new medication may interact agonistically or antagonistically (potentiate or decrease the intended therapeutic effect), causing significant morbidity and mortality around the world. Drug-drug and food-drug interactions may occur, and so-called "natural drugs" used in alternative medicine can have dangerous adverse effects. For example, extracts of St John's wort (Hypericum perforatum), a phytotherapic used for treating mild depression are known to cause an increase in the cytochrome P450 enzymes responsible for the metabolism and elimination of many drugs, so patients taking it are likely to experience a reduction in blood levels of drugs they are taking for other purposes, such as cancer chemotherapeutic drugs, protease inhibitors for HIV and hormonal contraceptives.

Signalling pathways of E.coli CheB, when activated by CheA, acts as a methylesterase, removing methyl groups from glutamate residues on the cytosolic side of the receptor; it works antagonistically with CheR, a methyltransferase, which adds methyl residues to the same glutamate residues. If the level of an attractant remains high, the level of phosphorylation of CheA (and, therefore, CheY and CheB) will remain low, the cell will swim smoothly, and the level of methylation of the MCPs will increase (because CheB-P is not present to demethylate). The MCPs no longer respond to the attractant when they are fully methylated; therefore, even though the level of attractant might remain high, the level of CheA-P (and CheB-P) increases and the cell begins to tumble. The MCPs can be demethylated by CheB-P, and, when this happens, the receptors can once again respond to attractants.