Each respiratory bronchiole supplies the alveoli held in each acinus accompanied by a pulmonary artery branch.
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The lobule is supplied by a terminal bronchiole that branches into respiratory bronchioles. The respiratory bronchioles supply the alveoli in each acinus and is accompanied by a pulmonary artery branch. Each lobule is enclosed by an interlobular septa. Each acinus is incompletely separated by an interlobular septa.
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The conducting zone of the respiratory tract ends at the terminal bronchioles when they branch into the respiratory bronchioles. This marks the beginning of an acinus which includes the respiratory bronchioles, the alveolar ducts, alveolar sacs, and alveoli. This is also called the terminal respiratory unit. An acinus measures up to 10 mm in diameter.
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Secretory cells are found in a group, or acinus (plural, acini). Each acinus is located at the terminal part of the gland connected to the ductal system, with many acini within each lobule of the gland. Each acinus consists of a single layer of cuboidal epithelial cells surrounding a lumen, a central opening where the saliva is deposited after being produced by the secretory cells. The three forms of acini are classified in terms of the type of epithelial cell present and the secretory product being produced: serous, mucoserous and mucous.
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The end of the respiratory bronchioles in the lungs mark the beginning of a pulmonary acinus that includes the alveolar ducts, alveolar sacs, and alveoli.
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The histopathologic features of pancreatic acinar metaplasia are: (1) the presence of cell clusters that resembles a many-lobed "berry" (an acinus), with (2) cells that are histomorphologically identical to the glands of the exocrine pancreas.
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The hepatic lobule can be described in terms of metabolic "zones", describing the hepatic acinus (terminal acinus). Each zone is centered on the line connecting two portal triads and extends outwards to the two adjacent central veins. The periportal zone I is nearest to the entering vascular supply and receives the most oxygenated blood, making it least sensitive to ischemic injury while making it very susceptible to viral hepatitis. Conversely, the centrilobular zone III has the poorest oxygenation, and will be most affected during a time of ischemia.
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The cells with this role form clusters () around small ducts, and are arranged in lobes that have thin fibrous walls. The cells of each acinus secrete inactive digestive enzymes called zymogens into the small intercalated ducts which they surround. In each acinus, the cells are pyramid- shaped and situated around the intercalated ducts, with the nuclei resting on the basement membrane, a large endoplasmic reticulum, and a number of zymogen granules visible within the cytoplasm. The intercalated ducts drain into larger intralobular ducts within the lobule, and finally interlobular ducts.
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Acini di pepe are a form of pasta. The name is Italian for "seeds of pepper". Acini is the plural of acino whose root is the Latin word acinus. In both Latin and Italian, the word means "grape" or "grape-stones".
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Centroacinar cells are spindle-shaped cells in the exocrine pancreas. They represent an extension of the intercalated duct into each pancreatic acinus. These cells are commonly known as duct cells, and secrete an aqueous bicarbonate solution under stimulation by the hormone secretin. They also secrete mucin.
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The human gene API5 encodes the protein Apoptosis inhibitor 5. This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.
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The serous demilune is an artifact from traditional methods of preparing samples. Samples are traditionally preserved and fixed in formaldehyde. When samples were preserved by quick-freezing in liquid nitrogen and then fixed with osmium tetraoxide in acetone, no demilunes were found. Examination showed that the serous cells and mucosal cells were aligned in the acinus.
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Black and white microphotograph of Feulgen stained, intact tick salivary glands infected by deer tick virus. Hypotrophied salivary acinus filled with amorphous masses of pinkstaining (=Feulgen positive) material (arrows). Scale bar = 10 µm. Feulgen stain is a staining technique discovered by Robert Feulgen and used in histology to identify chromosomal material or DNA in cell specimens.
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These are not associated with fibrosis (scarring). A fourth type known as irregular emphysema involves the acinus irregularly and is associated with fibrosis. Though the subtypes can be seen on imaging they are not well-defined clinically. Only the first two types of emphysema – centrilobular, and panlobular are associated with significant airflow obstruction, with that of centrilobular emphysema around 20 times more common than panlobular.
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The resulting increased blood flow to the acini allows the production of more saliva. In addition, Substance P can bind to Tachykinin NK-1 receptors leading to increased intracellular calcium concentrations and subsequently increased saliva secretion. Lastly, both parasympathetic and sympathetic nervous stimulation can lead to myoepithelium contraction which causes the expulsion of secretions from the secretory acinus into the ducts and eventually to the oral cavity. Sympathetic stimulation results in the release of norepinephrine.
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The LiMAx test is an innovative enzymatic liver function test. 13C-methacetin, a selective metabolite of the liver specific cytochrome P450 1A2 is administered intravenously. Via the bloodstream the drug is transported to the liver and immediately metabolized to paracetamol and ultimately to 13CO2 (Fig. 1), which is in turn transported via the bloodstream to the lung and exhaled. Cytochrome P450 1A2 is evenly distributed over all the cells of a liver acinus,C.
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Histatins are antimicrobial and antifungal proteins, and have been found to play a role in wound-closure. A significant source of histatins is found in the serous fluid secreted by Ebner's glands, salivary glands at the back of the tongue, and produced by Acinus cells. Here they offer some early defense against incoming microbes. The three major histatins are 1, 3, and 5, which contains 38, 32, and 24 amino acids, respectively.
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The intercalated duct, also called intercalary duct (ducts of Boll), is the portion of an exocrine gland leading directly from the acinus to a striated duct. The intercalated duct forms part of the intralobular duct. This duct has the thinnest epithelium of any part of the duct system, and the epithelium is usually classified as "low" simple cuboidal. They are found in both the pancreas \- "Mammal, pancreas (LM, Medium)" and in salivary glands.
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A lobule of the lung enclosed in septa and supplied by a terminal bronchiole that branches into the respiratory bronchioles. Each respiratory bronchiole supplies the alveoli held in each acinus accompanied by a pulmonary artery branch. A pulmonary lobule is the portion of the lung ventilated by one bronchiole. Bronchioles are approximately 1 mm or less in diameter and their walls consist of ciliated cuboidal epithelium and a layer of smooth muscle.
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A primary pulmonary lobule is that part of the acinus that includes the alveolar ducts, sacs, and alveoli but does not include the respiratory bronchioles. The unit described as the secondary pulmonary lobule is the lobule most referred to as the pulmonary lobule or respiratory lobule. This lobule is a discrete unit that is the smallest component of the lung that can be seen without aid. The secondary pulmonary lobule is likely to be made up of between 30 and 50 primary lobules.
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These glands, along with additional minor salivary glands, secrete a rich mixture of biological chemicals, electrolytes, proteins, genetic material, polysaccharides, and other molecules. Most of these substances enter the salivary gland acinus and duct system from the surrounding capillaries via the intervening tissue fluid, although some substances are produced within the glands themselves. The level of each salivary component varies considerably depending on the health status of the individual and the presence of disease (oral or systemic). By measuring these components in the saliva, it is possible to screen for a variety of infections, allergies, hormonal disturbances, and neoplasms.
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PaSCs are located within the peri-acinar spaces of the pancreas and extrude long cytoplasmic processes that surround the base of the acinus. PaSCs compose 4% of the total cell mass in the gland Stellate cells derive their name from their star shape and are located in other organs such as the kidney and lungs. The cells are located in periductal and perivascular regions of the pancreas and contain vitamin A lipid droplets in their cytoplasm. PaSCs engage in disease pathogenesis by transforming from a quiescent state into an activated state, which is also known as a “myofibroblastic” state.
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The lacrimal gland is a compound tubuloacinar gland, it is made up of many lobules separated by connective tissue, each lobule contains many acini. The acini composed of large serous cells which, produce a watery serous secretion, serous cells are filled with lightly stained secretory granules and surrounded by well- developed myoepithelial cells and a sparse, vascular stroma. Each acinus consists of a grape-like mass of lacrimal gland cells with their apices pointed to a central lumen. The central lumen of many of the units converge to form intralobular ducts, and then they unite to form interlobular ducts.
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The SAF-A/B, Acinus and PIAS (SAP) domain is located at the N-terminal of PIAS proteins. This evolutionarily conserved domain is found in proteins ranging from yeast to human and is shared by other chromatin-binding proteins, such as scaffold attachment factor A and B. The SAP domain can recognize and bind to AT-rich DNA sequences present in scaffold-attachment regions/matrix-attachment regions. These elements are frequently found near gene enhancers and interact with nuclear matrix proteins to provide a unique nuclear microenvironment for transcriptional regulation. An LXXLL signature motif is present within the SAP domain of all PIAS proteins.
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